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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Corticosterone acetate is a long‑acting glucocorticoid prodrug that is enzymatically converted into active corticosterone. It binds intracellular glucocorticoid receptors (GR), modulating transcription of inflammatory, metabolic and stress‑response genes. It suppresses cytokine synthesis, inhibits immune‑cell trafficking and alters glucose‑lipid metabolism.
Benefits and Advantages
Used in adrenal‑axis modelling, glucocorticoid‑receptor pathway studies, inflammation‑suppression research, stress physiology, metabolic‑syndrome experiments and endocrine‑pharmacology investigations.
Side Effects and Risks
Risks include immunosuppression, hyperglycemia, adrenal suppression, mood changes, osteoporosis and GI irritation. Handle as a potent steroid hormone precursor.
Datasheet
| Molecular Formula | C23H32O5 |
|---|---|
| Molecular Weight | 388.5 g/mol |
| CAS Number | 1173-26-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Corticosterone acetate; 1173-26-8; Corticosterone 21-acetate; KN17U0V6BL; DTXSID301020284 |
| IUPAC/Chemical Name | [2-[(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| InChl Key | WKQCPUMQBMFPLC-ZWFCQKKLSA-N |
| InChl Code | InChI=1S/C23H32O5/c1-13(24)28-12-20(27)18-7-6-17-16-5-4-14-10-15(25)8-9-22(14,2)21(16)19(26)11-23(17,18)3/h10,16-19,21,26H,4-9,11-12H2,1-3H3/t16-,17-,18+,19-,21+,22-,23-/m0/s1 |
| References |
3D Conformer.
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