7-KETO-DHEA
7-Keto-DHEA is a non-hormonal metabolite of dehydroepiandrosterone (DHEA) that is involved in regulating energy expenditure and thermogenesis. It is commonly used in formulations aimed at weight management and metabolic support. Benefits include potential enhancement of fat oxidation and improved metabolic rate without direct androgenic or estrogenic effects. Side effects are generally mild and may include headache, gastrointestinal discomfort, or restlessness in sensitive individuals.
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Product Description
Mechanism of action
7‑Keto‑DHEA is an oxidised metabolite of dehydroepiandrosterone that does not convert to active androgens or oestrogens. It is thought to influence energy metabolism through modulation of thermogenic enzymes and mitochondrial activity, including possible effects on 7‑oxo derivatives and thyroid hormone pathways. The compound is primarily explored as a metabolic and weight‑management adjunct.
Benefits and advantages
Because it lacks direct androgenic activity, 7‑keto‑DHEA is considered a potentially safer alternative to DHEA in applications where endocrine stimulation is undesirable. Experimental and clinical data suggest possible benefits on body‑composition, basal metabolic rate and well‑being when used under professional supervision and combined with lifestyle interventions.
Side effects and risks
Although generally regarded as having a more favourable hormonal profile than DHEA, 7‑keto‑DHEA can still influence endocrine balance and interact with other hormonal therapies. Reported adverse events include insomnia, headache, gastrointestinal discomfort and mild changes in thyroid or sex‑hormone related parameters. Long‑term safety data are limited. This substance should only be handled and formulated within a controlled, regulated setting.
Datasheet
| Molecular Formula | C19H26O3 |
|---|---|
| Molecular Weight | 302.4 g/mol |
| CAS Number | 566-19-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | 7-Keto-dehydroepiandrosterone; 7-Keto-DHEA; 7-Oxodehydroepiandrosterone; 7-oxo-dehydroepiandrosterone; 2334LJD2E9 |
| IUPAC/Chemical Name | (3S,8R,9S,10R,13S,14S)-3-hydroxy-10,13-dimethyl-2,3,4,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-7,17-dione |
| InChl Key | KPRGOTLNGIBVFL-GINZOMEDSA-N |
| InChl Code | InChI=1S/C19H26O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-14,17,20H,3-9H2,1-2H3/t12-,13-,14-,17-,18-,19-/m0/s1 |
| References |
3D Conformer.
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