TOBRAMYCIN SULPHATE
Tobramycin sulphate is an aminoglycoside antibiotic inhibiting 30S ribosomal function. Used for severe gramnegative infections and inhaled for cystic fibrosis. Side effects include nephrotoxicity, ototoxicity, and neuromuscular blockade. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
TOBRAMYCIN SULPHATE exerts multiaxis biochemical modulation involving enzymaticcascade interference, receptormediated signalling adjustment, oxidativestress balancing, mitochondrialrespiratory modulation, ionchannel behaviour influence, cytoskeletalarchitecture modification and transcriptionfactor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membraneanchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP/DAG turnover, cAMP regulation, ATP flux and cellular redoxstate stability.
Benefits & Applications
- Receptorligand interaction and docking studies
- Kinase/catalytic pathway profiling
- Mitochondrial ATP/ROS functional modelling
- Multiomics integration research
- Cytoskeletal and membranedynamics analysis
- Apoptosis, autophagy and survivalpathway investigations
- SAR/QSAR modelling and molecular optimisation
Risks & Side Effects
- ROS accumulation and oxidativestress imbalance
- Mitochondrial overload or ETC suppression
- Ionchannel destabilisation (Ca²⁺/Na⁺/K⁺)
- Cytoskeletal disruption and membrane integrity loss
- Dosedependent cytotoxicity
- Inflammatory cascade activation
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H37N5O9·H2SO4 |
|---|---|
| Molecular Weight | 1425.4 g/mol |
| CAS Number | 49842-07-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | TOBRAMYCIN SULFATE; Gernebcin; Nebicina; Obracin; Nebcin |
| IUPAC/Chemical Name | bis((2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol);sulfuric acid |
| InChl Key | NZKFUBQRAWPZJP-BXKLGIMVSA-N |
| InChl Code | InChI=1S/2C18H37N5O9.5H2O4S/c2*19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;5*1-5(2,3)4/h2*5-18,24-28H,1-4,19-23H2;5*(H2,1,2,3,4)/t2*5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;;;;;/m00…../s1 |
| References |
3D Conformer.
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