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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
TOBRAMYCIN SULPHATE (ID 27690) exerts multi‑axis biochemical modulation involving enzymatic‑cascade interference, receptor‑mediated signalling adjustment, oxidative‑stress balancing, mitochondrial‑respiratory modulation, ion‑channel behaviour influence, cytoskeletal‑architecture modification and transcription‑factor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membrane‑anchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP₃/DAG turnover, cAMP regulation, ATP flux and cellular redox‑state stability.
Benefits & Applications
- Receptor–ligand interaction and docking studies
- Kinase/catalytic pathway profiling
- Mitochondrial ATP/ROS functional modelling
- Multi‑omics integration research
- Cytoskeletal and membrane‑dynamics analysis
- Apoptosis, autophagy and survival‑pathway investigations
- SAR/QSAR modelling and molecular optimisation
Risks & Side Effects
- ROS accumulation and oxidative‑stress imbalance
- Mitochondrial overload or ETC suppression
- Ion‑channel destabilisation (Ca²⁺/Na⁺/K⁺)
- Cytoskeletal disruption and membrane integrity loss
- Dose‑dependent cytotoxicity
- Inflammatory cascade activation
Datasheet
| Molecular Formula | C18H37N5O9·H2SO4 |
|---|---|
| Molecular Weight | 1425.4 g/mol |
| CAS Number | 49842-07-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | TOBRAMYCIN SULFATE; Gernebcin; Nebicina; Obracin; Nebcin |
| IUPAC/Chemical Name | bis((2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol);sulfuric acid |
| InChl Key | NZKFUBQRAWPZJP-BXKLGIMVSA-N |
| InChl Code | InChI=1S/2C18H37N5O9.5H2O4S/c2*19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;5*1-5(2,3)4/h2*5-18,24-28H,1-4,19-23H2;5*(H2,1,2,3,4)/t2*5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;;;;;/m00…../s1 |
| References |
3D Conformer.
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