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Product Description
Mechanism of Action
SPECTINOMYCIN HCL (ID 27465) exhibits a broad and high‑complexity biochemical activity spectrum, modulating hierarchical signalling cascades, deep enzymatic networks, mitochondrial functional architecture, cytoskeletal integrity, transcription‑factor coordination and multi‑axis stress‑response systems. Its molecular conformation supports interaction with catalytic pockets, allosteric microdomains, transmembrane helices, regulatory scaffolds, ion‑channel architectures and redox‑buffering systems, producing wide‑ranging effects across metabolic, genomic, structural and electrophysiological layers.
Mechanistically, SPECTINOMYCIN HCL may alter phosphorylation topologies, reshape signalling‑cascade propagation (ERK, JNK, MAPK, PI3K–AKT), amplify or suppress second‑messenger concentrations (Ca²⁺, cAMP, IP₃, DAG), modify mitochondrial membrane polarity, shift ATP/ADP cycling behaviour, regulate ROS‑leakage thresholds and influence global metabolic flux distribution. Its capacity to integrate signals from cytosolic, organelle‑bound and membrane‑anchored proteins makes it suitable for advanced mechanistic interrogation.
High‑Level Research Applications
- Deep kinome‑mapping & systems‑level pathway‑interference analysis
- Structural docking, ligand‑stability modelling & conformational dynamics
- Mitochondrial‑stress analysis including ETC complex modelling
- UPR, ER‑stress & integrated autophagy/mitophagy evaluation
- Multi‑omics network reconstruction (RNA‑seq, phosphoproteomics, metabolomics)
- Membrane‑dynamics and cytoskeletal mechanotransduction studies
- Advanced cell‑fate modelling across apoptosis, necroptosis & ferroptosis axes
- Predictive SAR/QSAR pipelines using machine‑learning optimisation
Toxicodynamics & Cellular Risk Spectrum
- Rapid ROS escalation & antioxidant‑system saturation
- Mitochondrial fragmentation or ETC suppression
- Severe ionic‑flux dysregulation (Ca²⁺, Na⁺, K⁺)
- Cytoskeletal collapse & membrane‑integrity compromise
- Inflammatory upregulation (NF‑κB, STAT, IRF)
- Activation of programmed‑cell‑death pathways
- Epigenetic drift involving methylation & acetylation instability
For expert laboratory use only — not for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C14H36Cl2N2O12 |
|---|---|
| Molecular Weight | 495.3 g/mol |
| CAS Number | 22189-32-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Easily soluble in cold water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Spectinomycin hydrochloride; Spectinomycin HCl; Spectinomycin hydrochloride hydrate; Espectinomicina dihydrochloride pentahydrate; Spectogard |
| IUPAC/Chemical Name | (1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one;pentahydrate;dihydrochloride |
| InChl Key | DCHJOVNPPSBWHK-UXXUFHFZSA-N |
| InChl Code | InChI=1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1……./s1 |
| References |
3D Conformer.
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