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Product Description
Mechanism of Action
RIFAMYCIN (ID 27366) engages in multi‑layer biochemical interactions affecting enzyme cascades, receptor‑regulated signalling, oxidative‑stress systems, mitochondrial respiration, ion‑channel dynamics, cytoskeletal mechanics and transcription‑factor pathway coordination. Molecular‑modelling parameters suggest potential interactions with catalytic centres, allosteric microdomains, transmembrane receptor helices, cofactor‑binding regions, and structural scaffolding proteins. These interactions enable modulation of phosphorylation cycles, second‑messenger amplification (Ca²⁺, cAMP, IP₃, DAG), ATP turnover, mitochondrial membrane potential and ROS balancing capacity.
Benefits and Applications
- Receptor‑ligand affinity mapping and molecular docking
- Enzyme‑kinetic pathway modelling and catalytic‑flux analysis
- Mitochondrial bioenergetics profiling and redox‑state research
- Multi‑omics studies (transcriptomics, metabolomics, proteomics)
- Cytoskeletal architecture analysis and membrane‑dynamics modelling
- Apoptosis, necroptosis, autophagy and ferroptosis pathway assays
- SAR and QSAR‑driven molecular optimisation
- Pharmacodynamic and mechanistic dose‑response modelling
Risks & Side Effects
- Oxidative imbalance and ROS escalation
- Mitochondrial overload or suppression of respiratory complexes
- Ion‑channel destabilisation (Na⁺/K⁺/Ca²⁺)
- Unintended receptor cross‑talk
- Cytoskeletal destabilisation
- Dose‑dependent cytotoxicity or programmed‑cell‑death activation
- Inflammatory transcriptional activation (NF‑κB, JNK, MAPK)
Datasheet
| Molecular Formula | C37H47NO12 |
|---|---|
| Molecular Weight | 697.8 g/mol |
| CAS Number | 6998-60-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Insoluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | RIFAMYCIN; Rifamycin SV; Rifamicine SV; Rifomycin SV; Rifamicina |
| IUPAC/Chemical Name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate |
| InChl Key | HJYYPODYNSCCOU-ODRIEIDWSA-N |
| InChl Code | InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1 |
| References |
3D Conformer.
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