DIHYDROSTREPTOMYCIN SULPHATE

Dihydrostreptomycin is an aminoglycoside antibiotic inhibiting bacterial protein synthesis. Side effects include nephrotoxicity and irreversible hearing loss. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 800afb7d6053 Category: Tag:

Product Description


Mechanism of Action

Dihydrostreptomycin sulfate is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit, inhibiting protein synthesis and causing mistranslationmediated bactericidal effects. Reduction of streptomycin improves stability but increases ototoxicity risk.

Benefits and Advantages

Used in aminoglycosidemechanism modelling, bacterial translation research, resistancepathway studies, and ribosomalbinding assays.

Side Effects and Risks

Risks include irreversible hearing loss, vestibular dysfunction, nephrotoxicity and neuromuscular blockade. Handle with aminoglycosideclass containment.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C21H43N7O16S

Molecular Weight

681.7 g/mol

CAS Number

1425-61-2

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

Streptomycin, dihydro-, sulfate; RefChem:1099086; Dihydrostreptomycin sulphate; 1425-61-2; Citrocil

IUPAC/Chemical Name

2-[(1R,2R,3S,4R,5R,6S)-3-(diaminomethylideneamino)-4-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-(methylamino)oxan-2-yl]oxy-4-hydroxy-4-(hydroxymethyl)-5-methyloxolan-2-yl]oxy-2,5,6-trihydroxycyclohexyl]guanidine;sulfuric acid

InChl Key

GSPKOIJAMLDYCY-RMIBZTJPSA-N

InChl Code

InChI=1S/C21H41N7O12.H2O4S/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35;1-5(2,3)4/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28);(H2,1,2,3,4)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+;/m0./s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/121459;

3D Conformer.

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