About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Colistimethate sodium is an inactive prodrug converted to colistin (polymyxin E), a cationic lipopeptide antibiotic. Active colistin binds lipid A within gramnegative bacterial outer membranes, disrupting membrane integrity and causing rapid cell death. It is highly effective against multidrugresistant *Pseudomonas*, *Acinetobacter* and *Klebsiella* species.
Benefits and Advantages
Used in MDRpathogen modelling, polymyxinbinding studies, membranepermeabilization assays, endotoxin neutralization research and PK/PD evaluations in resistantbacteria simulations.
Side Effects and Risks
Risks include nephrotoxicity, neurotoxicity, neuromuscular blockade and hypersensitivity. Handle with strict polymyxinsafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C45H85N13O10 |
|---|---|
| Molecular Weight | 968.2 g/mol |
| CAS Number | 8068-28-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Appreciable |
| Purity | Purity information is available upon request (COA). |
| Synonym | Colimycine; Methacolimycin; Alficetin; Colifin 1 miu; Colifin 2 miu |
| IUPAC/Chemical Name | 6-methyl-N-[2-[(2S,5S,8S,11S,14S,17S,20S,23S)-8,11,14,20-tetrakis(2-aminoethyl)-5-[(1R)-1-hydroxyethyl]-17,23-bis(2-methylpropyl)-3,6,9,12,15,18,21,24-octaoxo-1,4,7,10,13,16,19,22-octazacyclotetracos-2-yl]ethyl]octanamide |
| InChl Key | RPABDKTXMKOGKI-OYTUFZPASA-N |
| InChl Code | InChI=1S/C45H85N13O10/c1-8-27(6)11-9-10-12-36(60)50-22-17-33-42(65)58-37(28(7)59)45(68)55-32(16-21-49)39(62)51-29(13-18-46)38(61)52-30(14-19-47)40(63)56-34(23-25(2)3)43(66)53-31(15-20-48)41(64)57-35(24-26(4)5)44(67)54-33/h25-35,37,59H,8-24,46-49H2,1-7H3,(H,50,60)(H,51,62)(H,52,61)(H,53,66)(H,54,67)(H,55,68)(H,56,63)(H,57,64)(H,58,65)/t27?,28-,29+,30+,31+,32+,33+,34+,35+,37+/m1/s1 |
| References |
3D Conformer.
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