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Product Description
Mechanism of Action
Clindamycin phosphate is a water‑soluble prodrug converted by phosphatases to active clindamycin. It retains full lincosamide mechanisms: 50S ribosomal binding and inhibition of transpeptidation and elongation. The phosphate form is useful for parenteral and topical formulations.
Benefits and Advantages
Used in prodrug‑activation studies, ribosomal‑binding assays, anaerobic‑infection modelling, toxin‑inhibition research and PK/PD optimisation.
Side Effects and Risks
Risks include diarrhea, pseudomembranous colitis, hypersensitivity, hepatotoxicity and GI irritation. Handle with lincosamide precautions.
Datasheet
| Molecular Formula | C18H34ClN3O8PS |
|---|---|
| Molecular Weight | 505.0 g/mol |
| CAS Number | 24729-96-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Clindamycin phosphate; 24729-96-2; Cleocin phosphate; Clindets; Cleocin T |
| IUPAC/Chemical Name | [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate |
| InChl Key | UFUVLHLTWXBHGZ-MGZQPHGTSA-N |
| InChl Code | InChI=1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1 |
| References |
3D Conformer.
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