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Product Description
Mechanism of Action
Potassium clavulanate is a β‑lactamase inhibitor that irreversibly acylates serine β‑lactamases, preventing hydrolysis of β‑lactam antibiotics. As a “suicide inhibitor,” it binds the enzyme and undergoes rearrangement, forming a stable inactive complex. It protects penicillins from degradation by common plasmid‑encoded β‑lactamases.
Benefits and Advantages
Used in β‑lactamase‑mechanism studies, inhibitor–enzyme kinetics research, combination‑antibiotic development, resistance‑pathway modelling and synergy assays with penicillins.
Side Effects and Risks
Risks include hepatic enzyme elevation, hypersensitivity, GI upset and rare cholestatic jaundice. Handle with β‑lactam inhibitor precautions.
Datasheet
| Molecular Formula | C8H8KNO5 |
|---|---|
| Molecular Weight | 237.25 g/mol |
| CAS Number | 61177-45-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 3.37e+02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Potassium clavulanate; 61177-45-5; CLAVULANATE POTASSIUM; Amonate; BRL 14151K |
| IUPAC/Chemical Name | potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| InChl Key | ABVRVIZBZKUTMK-JSYANWSFSA-M |
| InChl Code | InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1 |
| References |
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