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Product Description
Mechanism of action
Cefpiramide is a third‑generation parenteral cephalosporin with broad gram-negative activity and a long elimination half‑life. It binds PBPs and inhibits bacterial cell-wall synthesis. Its prolonged action makes it useful in sustained exposure PK/PD modelling and severe infection studies.
Benefits and advantages
Used in PK/PD research, gram-negative susceptibility assays, β‑lactam resistance evaluation, nosocomial-infection modelling, and cephalosporin structural optimisation studies. Particularly valuable in studying time-dependent killing dynamics.
Side effects and risks
Risks include hypersensitivity, hepatic enzyme variations, GI disturbances and possible nephrotoxicity at high exposures. Handle with standard β‑lactam precautions.
Datasheet
| Molecular Formula | C25H26N8O7S2 |
|---|---|
| Molecular Weight | 612.6 g/mol |
| CAS Number | 70797-11-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 6.68e-02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | cefpiramide; 70797-11-4; Cefpiramido; Cefpiramidum; Cefpiramida |
| IUPAC/Chemical Name | (6R,7R)-7-[[(2R)-2-(4-hydroxyphenyl)-2-[(6-methyl-4-oxo-1H-pyridine-3-carbonyl)amino]acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| InChl Key | PWAUCHMQEXVFJR-PMAPCBKXSA-N |
| InChl Code | InChI=1S/C25H24N8O7S2/c1-11-7-16(35)15(8-26-11)20(36)27-17(12-3-5-14(34)6-4-12)21(37)28-18-22(38)33-19(24(39)40)13(9-41-23(18)33)10-42-25-29-30-31-32(25)2/h3-8,17-18,23,34H,9-10H2,1-2H3,(H,26,35)(H,27,36)(H,28,37)(H,39,40)/t17-,18-,23-/m1/s1 |
| References |
3D Conformer.
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