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Product Description
Mechanism of action
Cefotiam hydrochloride is a second‑generation cephalosporin with strong activity against respiratory and urinary pathogens. It binds PBPs, blocking transpeptidase activity and disrupting bacterial cell-wall synthesis. It shows enhanced stability against certain β‑lactamases compared to earlier cephalosporins.
Benefits and advantages
Used in respiratory-pathogen research, urinary-infection models, β‑lactam SAR analysis, gram-negative susceptibility studies, and β‑lactamase-stability investigations. Its dual gram-positive/negative profile makes it suitable for broad-spectrum infection modelling.
Side effects and risks
Risks include allergic reactions, GI upset, mild hepatotoxicity, rare haematologic changes and injection-site irritation. Handle with β‑lactam antimicrobial safety measures.
Datasheet
| Molecular Formula | C18H23N9O4S3Cl |
|---|---|
| Molecular Weight | 598.6 g/mol |
| CAS Number | 66309-69-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cefotiam dihydrochloride; CEFOTIAM HYDROCHLORIDE; 66309-69-1; Cefotiam hcl; Ceradon |
| IUPAC/Chemical Name | (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrochloride |
| InChl Key | BWRRTAXZCKVRON-DGPOFWGLSA-N |
| InChl Code | InChI=1S/C18H23N9O4S3.2ClH/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10;;/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31);2*1H/t12-,15-;;/m1../s1 |
| References |
3D Conformer.
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