About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Cefiderocol is a siderophore cephalosporin designed to exploit bacterial iron-uptake systems. It chelates iron and is actively transported into gram-negative bacteria via siderophore receptors, achieving high periplasmic concentrations. Once inside, it binds PBPs and blocks peptidoglycan crosslinking, killing even highly resistant organisms including carbapenem-resistant Enterobacteriaceae and non-fermenters.
Benefits and advantages
Used at the forefront of multidrug-resistant (MDR) gram-negative research, iron-uptake pathway studies, β-lactamase-resistant drug design, PK/PD modelling against XDR strains, and siderophore-antibiotic conjugate investigations. A pivotal tool for studying “Trojan horse” antimicrobial strategies.
Side effects and risks
Risks include hypersensitivity, infusion-related reactions, potential selection of very resistant strains, and standard β-lactam adverse effects. Handle with advanced antimicrobial-containment practices.
Datasheet
| Molecular Formula | C30H34ClN7O10S2 |
|---|---|
| Molecular Weight | 752.2 g/mol |
| CAS Number | 1225208-94-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cefiderocol; 1225208-94-5; GSK2696266; S-649266; SZ34OMG6E8 |
| IUPAC/Chemical Name | (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-3-[[1-[2-[(2-chloro-3,4-dihydroxybenzoyl)amino]ethyl]pyrrolidin-1-ium-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
| InChl Key | DBPPRLRVDVJOCL-FQRUVTKNSA-N |
| InChl Code | InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
