About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Azosulfamide is a sulfonamide-class antimicrobial that acts by competitively inhibiting dihydropteroate synthase (DHPS), a key enzyme in the folate biosynthetic pathway of bacteria. By interfering with para-aminobenzoic acid (PABA) utilisation, azosulfamide blocks the formation of dihydropteroate and downstream tetrahydrofolate, an essential cofactor for nucleotide synthesis. This results in impaired DNA replication and reduced bacterial proliferation. Azosulfamide’s activity primarily extends to Gram‑positive organisms and selected Gram‑negative species.
Benefits and advantages
Azosulfamide is a valuable compound in folate–antimetabolite research, DHPS inhibitor development, bacterial resistance modelling (including sul gene mutations) and comparative sulfonamide potency assays. Its chemical structure offers predictable interactions in enzymology studies and assists in analysing metabolic bypass pathways in microorganisms.
Side effects and risks
Risks include hypersensitivity reactions, crystalluria, photosensitivity, gastrointestinal irritation and rare hematologic effects such as agranulocytosis. Proper protective handling is required to avoid inhalation or dermal exposure to sulfonamide powders.
Datasheet
| Molecular Formula | C18H14N4Na2O10S3 |
|---|---|
| Molecular Weight | 588.5 g/mol |
| CAS Number | 133-60-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | AZOSULFAMIDE; Drometil; 133-60-8; Leuconeoprontosil; Streptozon S |
| IUPAC/Chemical Name | disodium;6-acetamido-4-hydroxy-3-[(4-sulfamoylphenyl)diazenyl]naphthalene-2,7-disulfonate |
| InChl Key | YAZZWQFMIGUHKS-UHFFFAOYSA-L |
| InChl Code | InChI=1S/C18H16N4O10S3.2Na/c1-9(23)20-14-8-13-10(6-15(14)34(27,28)29)7-16(35(30,31)32)17(18(13)24)22-21-11-2-4-12(5-3-11)33(19,25)26;;/h2-8,24H,1H3,(H,20,23)(H2,19,25,26)(H,27,28,29)(H,30,31,32);;/q;2*+1/p-2 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
