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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Azithromycin is an azalide macrolide antibiotic that binds to the 50S ribosomal subunit near the peptidyl transferase centre, blocking bacterial protein synthesis by inhibiting translocation. Its extended lactone ring enhances acid stability and tissue penetration, providing long intracellular half‑life and high concentrations in phagocytes.
Benefits and advantages
Extensively used in microbiology, immunomodulation research, intracellular delivery studies, biofilm disruption investigations and ribosomal structural biology. Also key for studying macrolide resistance mechanisms such as erm‑mediated ribosomal methylation and efflux pumps.
Side effects and risks
Risks include QT prolongation, hepatic dysfunction, gastrointestinal disturbance and antimicrobial resistance selection. Handle with antibiotic API controls.
Datasheet
| Molecular Formula | C38H72N2O12 |
|---|---|
| Molecular Weight | 749.0 g/mol |
| CAS Number | 83905-01-5 |
| Storage Condition | Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. |
| Solubility | soluble in ethanol and DSMO, minimally soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | azithromycin; Zithromax; 83905-01-5; Hemomycin; Azithromycine |
| IUPAC/Chemical Name | (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one |
| InChl Key | MQTOSJVFKKJCRP-BICOPXKESA-N |
| InChl Code | InChI=1S/C38H72N2O12/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28/h20-33,35,41-43,45-46H,15-19H2,1-14H3/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
| References |
3D Conformer.
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