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Product Description
Mechanism of action
Amikacin sulfate is the sulfate salt of amikacin, providing improved solubility and stability for parenteral formulations. Its antibacterial mechanism is identical to that of amikacin base: irreversible binding to the 30S ribosomal subunit of susceptible bacteria, leading to inhibition of protein synthesis and rapid bactericidal activity.
Benefits and advantages
The sulfate salt form is used in injectable medicinal products for intravenous or intramuscular administration, ensuring reliable dissolution, sterility and shelf-life characteristics. It enables precise dosing in critical care and infectious disease settings where amikacin is selected for its robust activity against resistant Gram- negative organisms.
Side effects and risks
Toxicity, precautions and monitoring requirements are the same as those for amikacin base, including the risks of nephrotoxicity and ototoxicity. Manufacturing must comply with stringent good manufacturing practices, and workers should be protected from exposure to aerosolised or powdered antibiotic material.
Professional use only. Supplied exclusively to licensed manufacturers and healthcare institutions.
Datasheet
| Molecular Formula | C22H47N5O21S2 |
|---|---|
| Molecular Weight | 781.8 g/mol |
| CAS Number | 39831-55-5 |
| Storage Condition | Store at 20 deg to 25 °C (68 deg to 77 °F); excursions permitted between 15 deg to 30 °C (59 deg to 86 °F) |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | AMIKACIN SULFATE; 39831-55-5; Amikacin sulphate; Arikayce; BB-K8 |
| IUPAC/Chemical Name | (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;sulfuric acid |
| InChl Key | FXKSEJFHKVNEFI-GCZBSULCSA-N |
| InChl Code | InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1 |
| References |
3D Conformer.
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