WARFARIN
Warfarin is a vitamin K⁺ antagonist inhibiting synthesis of clotting factors II, VII, IX, and X. Used for anticoagulation in thromboembolic disorders. Side effects include bleeding, bruising, skin necrosis, teratogenicity, and numerous drugfood interactions. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
WARFARIN exhibits a highdimensional biochemical interaction matrix spanning signallingaxis disruption, catalyticdomain modulation, mitochondrialnetwork recalibration, ionflux redistribution, cytoskeletalarchitecture remodelling, membranepotential rebalancing and transcriptionfactor pathway restructuring. Its molecular topology supports interaction with catalytic residues, allosteric regulators, transmembrane helices, nucleotidebinding pockets, redoxbuffer modules and polymeric scaffolding complexes, enabling wideband influence across metabolic, structural, genomic and electrophysiological domains.
Mechanistically, WARFARIN may reshape phosphorylation maps across ERK/MAPK/JNK/p38 axes, alter PI3KAKT survivalbias, modulate Gprotein coupling geometry, redistribute Ca²⁺ microdomain waveforms, adjust IP/DAG signalling topology and recalibrate cAMPPKA amplitude. Mitochondrial impacts include ETCcomplex rebalancing, ATP/ADP cycle modulation, ROSthreshold displacement, mitochondrial membranepotential polarity shifts and crossorganelle stress signalling.
HighPrecision
- Kinomescale interference & catalyticcascade modelling
- Highresolution docking & conformationalflow prediction
- UPR/ERstress & autophagy/mitophagy integration networks
- Full multiomics reconstruction (RNAseq, proteomics, phosphoproteomics, metabolomics)
- Cytoskeletal forcemapping & polymer turnover dynamics
- Cellfate modelling: apoptosis, necroptosis, ferroptosis, parthanatos
- AIdriven SAR/QSAR predictive simulation
Toxicodynamics & Cellular Hazard Spectrum
- Excessive ROS accumulation & antioxidantbuffer collapse
- Mitochondrial fragmentation or ETC suppression
- Hyperdisruption of Na⁺/K⁺/Ca²⁺ ionicgradients
- Cytoskeletal degradation & membrane-integrity failure
- Inflammatory masterswitch activation (NF-κB/STAT/IRF)
- Multiaxis programmed-cell-death induction
- Epigenetic drift across methylation & acetylation layers
For expert laboratory research only not intended for biological use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C19H16O4 |
|---|---|
| Molecular Weight | 308.3 g/mol |
| CAS Number | 81-81-2 |
| Storage Condition | Warfarin /therapeutic/ prepn should be stored at a temp less than 40 °C, preferably between 15-30 °C; warfarin potassium & warfarin sodium tablets should be stored in tight, light-resistant containers & warfarin sodium powder for injection should be protected from light. Reconstituted solutions of warfarin sodium should be used immediately. /Warfarin potassium & warfarin sodium/ |
| Solubility | 0.002 % (NIOSH, 2024) |
| Purity | Purity information is available upon request (COA). |
| Synonym | warfarin; 81-81-2; Coumafene; Zoocoumarin; Coumafen |
| IUPAC/Chemical Name | 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one |
| InChl Key | PJVWKTKQMONHTI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3 |
| References |
3D Conformer.
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