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Product Description
Mechanism of Action
VERAPAMIL HCL (ID 27812) exhibits a high‑dimensional biochemical interaction matrix spanning signalling‑axis disruption, catalytic‑domain modulation, mitochondrial‑network recalibration, ion‑flux redistribution, cytoskeletal‑architecture remodelling, membrane‑potential rebalancing and transcription‑factor pathway restructuring. Its molecular topology supports interaction with catalytic residues, allosteric regulators, transmembrane helices, nucleotide‑binding pockets, redox‑buffer modules and polymeric scaffolding complexes, enabling wide‑band influence across metabolic, structural, genomic and electrophysiological domains.
Mechanistically, VERAPAMIL HCL may reshape phosphorylation maps across ERK/MAPK/JNK/p38 axes, alter PI3K–AKT survival‑bias, modulate G‑protein coupling geometry, redistribute Ca²⁺ microdomain waveforms, adjust IP₃/DAG signalling topology and recalibrate cAMP–PKA amplitude. Mitochondrial impacts include ETC‑complex rebalancing, ATP/ADP cycle modulation, ROS‑threshold displacement, mitochondrial membrane‑potential polarity shifts and cross‑organelle stress signalling.
High‑Precision Research Applications
- Kinome‑scale interference & catalytic‑cascade modelling
- High‑resolution docking & conformational‑flow prediction
- UPR/ER‑stress & autophagy/mitophagy integration networks
- Full multi‑omics reconstruction (RNA‑seq, proteomics, phosphoproteomics, metabolomics)
- Cytoskeletal force‑mapping & polymer turnover dynamics
- Cell‑fate modelling: apoptosis, necroptosis, ferroptosis, parthanatos
- AI‑driven SAR/QSAR predictive simulation
Toxicodynamics & Cellular Hazard Spectrum
- Excessive ROS accumulation & antioxidant‑buffer collapse
- Mitochondrial fragmentation or ETC suppression
- Hyper‑disruption of Na⁺/K⁺/Ca²⁺ ionic‑gradients
- Cytoskeletal degradation & membrane‑integrity failure
- Inflammatory master‑switch activation (NF‑κB/STAT/IRF)
- Multi‑axis programmed‑cell‑death induction
- Epigenetic drift across methylation & acetylation layers
For expert laboratory research only — not intended for biological use.
Datasheet
| Molecular Formula | C27H39ClN2O4 |
|---|---|
| Molecular Weight | 491.1 g/mol |
| CAS Number | 152-11-4 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Light sensitive. /Verapamil hydrochloride/ |
| Solubility | Solubility (mg/mL): water 83, ethanol (200 proof) 26, propylene glycol 93, ethanol (190 proof) >100, methanol >100, 2-propanol 4.6, ethyl acetate 1.0, DMF >100, methylene chloride >100, hexane 0.001; Freely soluble in chloroform, practically insoluble in ether /Verapamil hydrochloride/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | Verapamil hydrochloride; 152-11-4; Verapamil HCl; Verelan; Covera |
| IUPAC/Chemical Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile;hydrochloride |
| InChl Key | DOQPXTMNIUCOSY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H |
| References |
3D Conformer.
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