VALACYCLOVIR

Valacyclovir is an antiviral prodrug of acyclovir inhibiting viral DNA polymerase. Used for HSV and VZV infections. Side effects include headache, nausea, renal impairment, and rare neurotoxicity. Only GMP materials will be supplied, logistics all according to GDP.

SKU: d0384411d017 Category: Tag:

Product Description


Mechanism of Action

VALACYCLOVIR exhibits a highdimensional biochemical interaction matrix spanning signallingaxis disruption, catalyticdomain modulation, mitochondrialnetwork recalibration, ionflux redistribution, cytoskeletalarchitecture remodelling, membranepotential rebalancing and transcriptionfactor pathway restructuring. Its molecular topology supports interaction with catalytic residues, allosteric regulators, transmembrane helices, nucleotidebinding pockets, redoxbuffer modules and polymeric scaffolding complexes, enabling wideband influence across metabolic, structural, genomic and electrophysiological domains.

Mechanistically, VALACYCLOVIR may reshape phosphorylation maps across ERK/MAPK/JNK/p38 axes, alter PI3KAKT survivalbias, modulate Gprotein coupling geometry, redistribute Ca²⁺ microdomain waveforms, adjust IP/DAG signalling topology and recalibrate cAMPPKA amplitude. Mitochondrial impacts include ETCcomplex rebalancing, ATP/ADP cycle modulation, ROSthreshold displacement, mitochondrial membranepotential polarity shifts and crossorganelle stress signalling.

HighPrecision

  • Kinomescale interference & catalyticcascade modelling
  • Highresolution docking & conformationalflow prediction
  • UPR/ERstress & autophagy/mitophagy integration networks
  • Full multiomics reconstruction (RNAseq, proteomics, phosphoproteomics, metabolomics)
  • Cytoskeletal forcemapping & polymer turnover dynamics
  • Cellfate modelling: apoptosis, necroptosis, ferroptosis, parthanatos
  • AIdriven SAR/QSAR predictive simulation

Toxicodynamics & Cellular Hazard Spectrum

  • Excessive ROS accumulation & antioxidantbuffer collapse
  • Mitochondrial fragmentation or ETC suppression
  • Hyperdisruption of Na⁺/K⁺/Ca²⁺ ionicgradients
  • Cytoskeletal degradation & membrane-integrity failure
  • Inflammatory masterswitch activation (NF-κB/STAT/IRF)
  • Multiaxis programmed-cell-death induction
  • Epigenetic drift across methylation & acetylation layers

For expert laboratory research only not intended for biological use.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C13H20N6O4

Molecular Weight

324.34 g/mol

CAS Number

124832-26-4

Storage Condition

Store at 15 deg to 25 °C (59 deg to 77 °F). Dispense in a well-closed container as defined in the USP.

Solubility

Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.

Purity

Purity information is available upon request (COA).

Synonym

valacyclovir; Valaciclovir; 124832-26-4; ValACV; Zelitrex

IUPAC/Chemical Name

2-[(2-amino-6-oxo-1H-purin-9-yl)methoxy]ethyl (2S)-2-amino-3-methylbutanoate

InChl Key

HDOVUKNUBWVHOX-QMMMGPOBSA-N

InChl Code

InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1

References

https://pubchem.ncbi.nlm.nih.gov/compound/135398742;

3D Conformer.

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