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Product Description
Mechanism of Action
TRIIODOTHYRONINE (ID 27748) demonstrates multi‑layer biochemical influence across signalling hierarchies, catalytic‑domain regulation, mitochondrial‑network energetics, ion‑gradient stability, membrane electrochemistry, redox equilibrium and transcription‑factor axis alignment. Its molecular topology enables interaction with catalytic residues, allosteric nodes, hydrophobic receptor microdomains, transmembrane helices, redox‑buffer matrices and cytoskeletal scaffolds, resulting in wide‑spectrum modulation across metabolic, structural, electrophysiological and genomic systems.
Mechanistically, TRIIODOTHYRONINE may remodel phosphorylation flux across MAPK/ERK/JNK/p38 pathways, reshape PI3K–AKT survival topology, modify G‑protein coupling dynamics, reorganise Ca²⁺ signalling microdomains, influence IP₃/DAG cascade geometry and adjust cAMP–PKA amplitude distributions. Mitochondrial impacts include ETC‑complex rebalancing, ATP/ADP turnover pattern shifts, ROS‑threshold displacement, membrane‑potential polarity modulation and ER–mitochondrial stress‑cross‑talk regulation.
Advanced Research Applications
- Kinome‑scale interference mapping and catalytic‑cascade simulation
- High‑resolution docking and conformational‑transition modelling
- UPR/ER‑stress, autophagy–mitophagy and organelle‑network integration research
- Multi‑omics regulatory reconstruction (RNA‑seq, phosphoproteomics, metabolomics, proteomics)
- Cytoskeletal tension‑mapping and polymer‑turnover analysis
- Cell‑fate simulations (apoptosis, necroptosis, ferroptosis, parthanatos)
- Machine‑learning SAR/QSAR predictive optimisation
Toxicodynamics & Hazard Profile
- Accelerated ROS accumulation & antioxidant‑buffer saturation
- Mitochondrial fragmentation or ETC‑axis destabilisation
- Severe Na⁺/K⁺/Ca²⁺ ionic‑flux dysregulation
- Cytoskeletal collapse & membrane‑integrity failure
- Inflammatory‑axis hyperactivation (NF‑κB, STAT, IRF pathways)
- Activation of multi‑axis programmed‑cell‑death pathways
- Epigenetic methylation/acetylation drift
For expert laboratory research only — not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C15H12I3NO4 |
|---|---|
| Molecular Weight | 650.97 g/mol |
| CAS Number | 1823692 |
| Storage Condition | Commercially available liothyronine sodium tablets should be stored in tight containers at a temperature less than 40 °C, preferably between 15-30 °C. Commercially available liothyronine sodium injection should be stored at 2-8 °C. /Liothyronine sodium/ |
| Solubility | Very slightly soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | liothyronine; 3,3',5-Triiodo-L-thyronine; triiodothyronine; 6893-02-3; Liothyronin |
| IUPAC/Chemical Name | (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid |
| InChl Key | AUYYCJSJGJYCDS-LBPRGKRZSA-N |
| InChl Code | InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 |
| References |
3D Conformer.
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