TRIHEXYPHENIDYL HCL
Trihexyphenidyl HCl is an anticholinergic used for Parkinsons disease and drug-induced extrapyramidal symptoms. It reduces tremor and rigidity. Side effects include dry mouth, blurred vision, constipation, confusion, urinary retention, and risk of cognitive impairment in elderly patients. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
TRIHEXYPHENIDYL HCL demonstrates multilayer biochemical influence across signalling hierarchies, catalyticdomain regulation, mitochondrialnetwork energetics, iongradient stability, membrane electrochemistry, redox equilibrium and transcriptionfactor axis alignment. Its molecular topology enables interaction with catalytic residues, allosteric nodes, hydrophobic receptor microdomains, transmembrane helices, redoxbuffer matrices and cytoskeletal scaffolds, resulting in widespectrum modulation across metabolic, structural, electrophysiological and genomic systems.
Mechanistically, TRIHEXYPHENIDYL HCL may remodel phosphorylation flux across MAPK/ERK/JNK/p38 pathways, reshape PI3KAKT survival topology, modify Gprotein coupling dynamics, reorganise Ca²⁺ signalling microdomains, influence IP/DAG cascade geometry and adjust cAMPPKA amplitude distributions. Mitochondrial impacts include ETCcomplex rebalancing, ATP/ADP turnover pattern shifts, ROSthreshold displacement, membranepotential polarity modulation and ERmitochondrial stresscrosstalk regulation.
Advanced
- Kinomescale interference mapping and catalyticcascade simulation
- Highresolution docking and conformationaltransition modelling
- UPR/ERstress, autophagymitophagy and organellenetwork integration research
- Multiomics regulatory reconstruction (RNAseq, phosphoproteomics, metabolomics, proteomics)
- Cytoskeletal tensionmapping and polymerturnover analysis
- Cellfate simulations (apoptosis, necroptosis, ferroptosis, parthanatos)
- Machinelearning SAR/QSAR predictive optimisation
Toxicodynamics & Hazard Profile
- Accelerated ROS accumulation & antioxidantbuffer saturation
- Mitochondrial fragmentation or ETCaxis destabilisation
- Severe Na⁺/K⁺/Ca²⁺ ionic-flux dysregulation
- Cytoskeletal collapse & membrane-integrity failure
- Inflammatoryaxis hyperactivation (NF-κB, STAT, IRF pathways)
- Activation of multiaxis programmed-cell-death pathways
- Epigenetic methylation/acetylation drift
For expert laboratory research only not intended for biological or therapeutic exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H31NO·HCl |
|---|---|
| Molecular Weight | 337.9 g/mol |
| CAS Number | 52-49-3 |
| Storage Condition | Trihexyphenidyl hydrochloride tablets should be stored in tight containers at 15-30 °C. Trihexyphenidyl hydrochloride elixir should be stored at controlled room temperature (20-25 °C); freezing of the elixir should be avoided. |
| Solubility | >50.7 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Trihexyphenidyl hydrochloride; 52-49-3; Cyclodol; Parcopane; Romparkin |
| IUPAC/Chemical Name | 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride |
| InChl Key | QDWJJTJNXAKQKD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H |
| References |
3D Conformer.
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