About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
TOCILIZUMAB exerts multiaxis biochemical modulation involving enzymaticcascade interference, receptormediated signalling adjustment, oxidativestress balancing, mitochondrialrespiratory modulation, ionchannel behaviour influence, cytoskeletalarchitecture modification and transcriptionfactor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membraneanchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP/DAG turnover, cAMP regulation, ATP flux and cellular redoxstate stability.
Benefits & Applications
- Receptorligand interaction and docking studies
- Kinase/catalytic pathway profiling
- Mitochondrial ATP/ROS functional modelling
- Multiomics integration research
- Cytoskeletal and membranedynamics analysis
- Apoptosis, autophagy and survivalpathway investigations
- SAR/QSAR modelling and molecular optimisation
Risks & Side Effects
- ROS accumulation and oxidativestress imbalance
- Mitochondrial overload or ETC suppression
- Ionchannel destabilisation (Ca²⁺/Na⁺/K⁺)
- Cytoskeletal disruption and membrane integrity loss
- Dosedependent cytotoxicity
- Inflammatory cascade activation
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6428H9976N1716O2018S44 |
|---|---|
| Molecular Weight | 148000.0 g/mol |
| CAS Number | 375823-41-9 |
| Storage Condition | Store at 28°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | RefChem:1072364; 5-(2-(4-Hydroxyphenyl)Ethenyl)Benzene-1,3-Diol; 133294-37-8; 5-[2-(4-hydroxyphenyl)vinyl]benzene-1,3-diol; 1,3-Benzenediol, 5-[(1Z)-2-(4-hydroxyphenyl)ethenyl]- |
| IUPAC/Chemical Name | AntiIL6 receptor monoclonal antibody |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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