THYMOXAMINE HCL

Thymoxamine HCl is an alphaadrenergic antagonist used to treat urinary retention and vasospasm by relaxing smooth muscle. Side effects include hypotension, dizziness, nasal congestion, and tachycardia. Only GMP materials will be supplied, logistics all according to GDP.

SKU: 532b418f8886 Category: Tag:

Product Description


Mechanism of Action

THYMOXAMINE HCL exerts multiaxis biochemical modulation involving enzymaticcascade interference, receptormediated signalling adjustment, oxidativestress balancing, mitochondrialrespiratory modulation, ionchannel behaviour influence, cytoskeletalarchitecture modification and transcriptionfactor regulatory alignment. Its molecular topology supports potential interaction with catalytic residues, allosteric microdomains, membraneanchored receptor systems and intracellular signalling scaffolds. These interactions affect phosphorylation circuits, Ca²⁺ signalling, IP/DAG turnover, cAMP regulation, ATP flux and cellular redoxstate stability.

Benefits & Applications

  • Receptorligand interaction and docking studies
  • Kinase/catalytic pathway profiling
  • Mitochondrial ATP/ROS functional modelling
  • Multiomics integration research
  • Cytoskeletal and membranedynamics analysis
  • Apoptosis, autophagy and survivalpathway investigations
  • SAR/QSAR modelling and molecular optimisation

Risks & Side Effects

  • ROS accumulation and oxidativestress imbalance
  • Mitochondrial overload or ETC suppression
  • Ionchannel destabilisation (Ca²⁺/Na⁺/K⁺)
  • Cytoskeletal disruption and membrane integrity loss
  • Dosedependent cytotoxicity
  • Inflammatory cascade activation

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C16H26ClNO3

Molecular Weight

315.83 g/mol

CAS Number

964-52-3

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

>47.4 [ug/mL] (The mean of the results at pH 7.4)

Purity

Purity information is available upon request (COA).

Synonym

moxisylyte hydrochloride; 964-52-3; Thymoxamine hydrochloride; Moxisylyte HCl; Thymoxamine hcl

IUPAC/Chemical Name

[4-[2-(dimethylamino)ethoxy]-2-methyl-5-propan-2-ylphenyl] acetate;hydrochloride

InChl Key

IPWGSXZCDPTDEH-UHFFFAOYSA-N

InChl Code

InChI=1S/C16H25NO3.ClH/c1-11(2)14-10-15(20-13(4)18)12(3)9-16(14)19-8-7-17(5)6;/h9-11H,7-8H2,1-6H3;1H

References

https://pubchem.ncbi.nlm.nih.gov/compound/6420039;

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