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Product Description
Mechanism of Action
TETRANDRINE demonstrates a broad and highly integrated biochemical activity architecture involving multiaxis signalling interference, mitochondrial-network recalibration, catalyticdomain modulation, cytoskeletal restructuring, redoxequilibrium shaping, ionflux redistribution and transcriptionfactor pathway realignment. Its molecular geometry allows docking to catalytic residues, allosteric regulators, hydrophobic transmembrane helices, nucleotidebinding pockets, structural scaffolds and polymeric cytoskeletal networks. This enables TETRANDRINE to influence metabolic, structural, genomic, electrophysiological and stressadaptive systems simultaneously.
TETRANDRINE may modulate phosphorylation gradients, modify ERK/JNK/MAPK propagation speeds, influence PI3KAKT survival bias, shift Gprotein signalling states, control Ca²⁺ microdomain behaviour, alter IP/DAG cascades, and recalibrate cAMPPKA pathway amplitude. Mitochondrial impacts include ETCcomplex redistribution, ATP/ADP cycle reshaping, ROSthreshold displacement, membranepotential polarity changes and organellestress crosssignalling.
HighPrecision
- Ultrascale kinome disruption & catalyticcascade modelling
- Molecular docking & conformationalflow prediction
- UPR/ERstress and mitophagy/autophagy integration research
- Fullspectrum multiomics reconstruction (RNAseq, metabolomics, phosphoproteomics)
- Advanced cytoskeletal forcedistribution & polymerturnover analysis
- Cellfate simulation across apoptosis, ferroptosis, necroptosis & parthanatos
- AIenhanced SAR/QSAR simulation for molecular optimisation
Toxicodynamics & Hazard Spectrum
- Rapid ROS escalation & antioxidantbuffer collapse
- Mitochondrial fragmentation or ETC suppression
- Severe Ca²⁺/Na⁺/K⁺ ionflux destabilisation
- Cytoskeletal polymer breakdown & structuralintegrity failure
- Membrane rupture & lipidbilayer thinning
- Overactivation of inflammatory cascades (NF-κB, STAT, IRF)
- Activation of multiple programmed-cell-death pathways
- Epigenetic drift including methylation instability
For expert not intended for biological exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C38H42N2O6 |
|---|---|
| Molecular Weight | 622.7 g/mol |
| CAS Number | 518-34-3 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | tetrandrine; 518-34-3; D-Tetrandrine; (+)-Tetrandrine; Tetrandrin |
| IUPAC/Chemical Name | (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene |
| InChl Key | WVTKBKWTSCPRNU-KYJUHHDHSA-N |
| InChl Code | InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1 |
| References |
3D Conformer.
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