Succinylcholine Chloride

Succinylcholine chloride is a depolarizing neuromuscular blocker used for rapid sequence intubation. Side effects include hyperkalemia, malignant hyperthermia, bradycardia, and postoperative muscle pain. Only GMP materials will be supplied, logistics all according to GDP.

Product Description


Mechanism of Action

Succinylcholine Chloride demonstrates a multiaxis biochemical interference profile spanning catalyticdomain perturbation, mitochondrialnetwork recalibration, ionflux redistribution, membranepotential modulation, cytoskeletal remodelling, redoxequilibrium restructuring and transcriptionfactor pathway reprogramming. Its molecular architecture supports docking to catalytic residues, allosteric control nodes, transmembrane helices, nucleotidebinding sites, redoxbuffer matrices and polymeric scaffold proteins. This enables systemwide modulation across metabolic, structural, genomic and electrophysiological regulatory layers.

Mechanistic effects include redistribution of phosphorylation flux across ERK/MAPK/JNK/p38 signalling axes, modulation of PI3KAKT survivalpathway geometry, reconfiguration of Gprotein coupling logic, reshaping of Ca²⁺ microdomain behaviour, alteration of IP/DAG cascade topology and amplitude recalibration within the cAMPPKA axis. Mitochondrial influences include ETCcomplex rebalancing, ATP/ADP flux modelling shifts, ROSthreshold displacement, mitochondrialmembrane potential polarity adjustments and crossorganelle stresssignal propagation between ER and mitochondrial systems.

Advanced

  • Kinomelevel catalyticcascade interference mapping
  • Highprecision ligand docking & conformationaltransition simulations
  • UPR/ERstress, mitophagy & autophagicflux network modelling
  • Multiomics integration (RNAseq, proteomics, metabolomics, phosphoproteomics)
  • Cytoskeletal mechanics, forcedistribution profiling & polymer turnover
  • Cellfate modelling across apoptosis, necroptosis, ferroptosis & parthanatos
  • SAR/QSAR optimisation with machinelearningbased compound performance modelling

Toxicodynamics & Hazard Spectrum

  • Rapid ROS accumulation & antioxidantbuffer collapse
  • Mitochondrial fragmentation or ETC suppression
  • Severe Na⁺/K⁺/Ca²⁺ ionflux destabilisation
  • Cytoskeletal depolymerisation & membrane-integrity failure
  • Hyperactivation of NF-κB, STAT & IRF inflammatory regulators
  • Induction of multiaxis programmed-cell-death pathways
  • Epigenetic drift including methylation/acetylation instability

For expert laboratory research only not intended for biological use.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C14H30Cl2N2O4

Molecular Weight

361.3 g/mol

CAS Number

71-27-2

Storage Condition

Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.

Solubility

greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)

Purity

Purity information is available upon request (COA).

Synonym

Succinylcholine chloride; 71-27-2; Succinyldicholine chloride; Anectine; Midarine

IUPAC/Chemical Name

trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium dichloride

InChl Key

YOEWQQVKRJEPAE-UHFFFAOYSA-L

InChl Code

InChI=1S/C14H30N2O4.2ClH/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

References

https://pubchem.ncbi.nlm.nih.gov/compound/22475;

3D Conformer.

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