SALICYLAMIDE
Salicylamide is an analgesic and antipyretic that inhibits prostaglandin synthesis, similar to other salicylates but with a reduced risk of gastric irritation. Benefits include headache and mild pain relief. Side effects include nausea, dizziness, allergic reactions, and, rarely, liver enzyme elevation with prolonged use. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
SALICYLAMIDE displays a multidimensional biochemical activity profile integrating modulation of enzymatic pathways, receptormediated signalling, mitochondrial bioenergetics, oxidativestress homeostasis, ionchannel dynamics, membrane structural behaviour and transcriptionfactor regulation. Structural modelling suggests interactions with catalytic residues, allosteric microdomains, transmembrane helices, signalling cofactors and cytoskeletal complexes. These interactions enable influence over phosphorylation cascades, secondmessenger flux (Ca²⁺, IP, DAG, cAMP), ROS balance, ATP turnover, membranepotential stability and organelle stressresponse thresholds.
Benefits and Applications
- Receptorligand affinity analysis and docking studies
- Enzymekinetic profiling and catalyticflux pathway mapping
- Mitochondrialfunction modelling and ATP/ROS system evaluation
- Transcriptomic, metabolomic, proteomic and phosphoproteomic profiling
- Cytoskeletalarchitecture and membranedynamics exploration
- Apoptosis, autophagy, necroptosis and ferroptosis pathway modelling
- SAR/QSAR modelling and compoundoptimisation workflows
- Mechanistic pharmacodynamics and doseresponse simulation
Side Effects and Risks
- Oxidativestress imbalance and elevated ROS
- Mitochondrial overload or respiratorychain suppression
- Disruption of Ca²⁺/Na⁺/K⁺ ionhomeostasis
- Unintended receptor crosstalk or inhibitory signal interference
- Cytoskeletal destabilisation and membrane-integrity reduction
- Dosedependent cytotoxicity or programmed-cell-death activation
- Transcriptional and epigenetic instability
- Inflammatorycascade activation (NF-κB, MAPK, JNK)
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H7NO2 |
|---|---|
| Molecular Weight | 137.14 g/mol |
| CAS Number | 65-45-2 |
| Storage Condition | Salicylamide preparations generally should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15 and 30 °C. |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | salicylamide; 2-Hydroxybenzamide; 65-45-2; o-Hydroxybenzamide; Benzamide, 2-hydroxy- |
| IUPAC/Chemical Name | 2-hydroxybenzamide |
| InChl Key | SKZKKFZAGNVIMN-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) |
| References |
3D Conformer.
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