SALICYLAMIDE
Salicylamide is an analgesic and antipyretic that inhibits prostaglandin synthesis, similar to other salicylates but with a reduced risk of gastric irritation. Benefits include headache and mild pain relief. Side effects include nausea, dizziness, allergic reactions, and, rarely, liver enzyme elevation with prolonged use.
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Product Description
Mechanism of Action
SALICYLAMIDE (ID 27415) displays a multidimensional biochemical activity profile integrating modulation of enzymatic pathways, receptor‑mediated signalling, mitochondrial bioenergetics, oxidative‑stress homeostasis, ion‑channel dynamics, membrane structural behaviour and transcription‑factor regulation. Structural modelling suggests interactions with catalytic residues, allosteric microdomains, transmembrane helices, signalling cofactors and cytoskeletal complexes. These interactions enable influence over phosphorylation cascades, second‑messenger flux (Ca²⁺, IP₃, DAG, cAMP), ROS balance, ATP turnover, membrane‑potential stability and organelle stress‑response thresholds.
Benefits and Applications
- Receptor–ligand affinity analysis and docking studies
- Enzyme‑kinetic profiling and catalytic‑flux pathway mapping
- Mitochondrial‑function modelling and ATP/ROS system evaluation
- Transcriptomic, metabolomic, proteomic and phosphoproteomic profiling
- Cytoskeletal‑architecture and membrane‑dynamics exploration
- Apoptosis, autophagy, necroptosis and ferroptosis pathway modelling
- SAR/QSAR modelling and compound‑optimisation workflows
- Mechanistic pharmacodynamics and dose–response simulation
Side Effects and Risks
- Oxidative‑stress imbalance and elevated ROS
- Mitochondrial overload or respiratory‑chain suppression
- Disruption of Ca²⁺/Na⁺/K⁺ ion‑homeostasis
- Unintended receptor cross‑talk or inhibitory signal interference
- Cytoskeletal destabilisation and membrane‑integrity reduction
- Dose‑dependent cytotoxicity or programmed‑cell‑death activation
- Transcriptional and epigenetic instability
- Inflammatory‑cascade activation (NF‑κB, MAPK, JNK)
Datasheet
| Molecular Formula | C7H7NO2 |
|---|---|
| Molecular Weight | 137.14 g/mol |
| CAS Number | 65-45-2 |
| Storage Condition | Salicylamide preparations generally should be stored in well-closed containers at a temperature less than 40 °C, preferably between 15 and 30 °C. |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | salicylamide; 2-Hydroxybenzamide; 65-45-2; o-Hydroxybenzamide; Benzamide, 2-hydroxy- |
| IUPAC/Chemical Name | 2-hydroxybenzamide |
| InChl Key | SKZKKFZAGNVIMN-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10) |
| References |
3D Conformer.
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