ROLAPITANT
Rolapitant is a research-grade compound used in advanced pharmaceutical and biochemical studies. Chemical & Pharmacological Characteristics Experimental behavior is governed by solubility, stability, ionization state, and matrix interactions. Proper formulation control is essential. Mechanism of Action No single receptor-driven mechanism is assumed; observed effects are concentration- and context-dependent. It is primarily applied to investigate compound-specific mechanisms, physicochemical behavior, and analytical or formulation-relevant characteristics under controlled laboratory conditions.
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Product Description
Chemical & Pharmacological Characteristics
Experimental behavior is governed by solubility, stability, ionization state, and matrix interactions. Proper formulation control is essential.
Mechanism of Action
No single receptor-driven mechanism is assumed; observed effects are concentration- and context-dependent.
Interpretation should include matched controls to separate direct chemical effects from secondary stress responses.
Advanced Research Applications
- Analytical reference and quality control
- Formulation development and stability screening
- Compatibility testing with excipients and packaging
- Comparative toxicology benchmarking
- Documentation support for R&D workflows
Toxicodynamics & Cellular Hazard Spectrum
- Nonspecific cytotoxicity at high exposure
- Solubility or aggregation artifacts
- Matrix-dependent assay interference
- Handling-related irritation risk
- Dispose according to laboratory waste regulations
For expert laboratory research only – not intended for biological or therapeutic exposure.
Datasheet
| Molecular Formula | C25H26F6N2O2 |
|---|---|
| Molecular Weight | 500.5 g/mol |
| CAS Number | 552292-08-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Rolapitant; 552292-08-7; NLE429IZUC; Varuby; (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one |
| IUPAC/Chemical Name | (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one |
| InChl Key | FIVSJYGQAIEMOC-ZGNKEGEESA-N |
| InChl Code | InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/10311306; small-molecule |
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