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Product Description
Mechanism of Action
QUINAPRIL HCL demonstrates an exceptionally broad biochemical influence profile integrating multiaxis signalling interference, deep enzymatic cascade modulation, mitochondrialnetwork reprogramming, ionflux recalibration, structuralprotein remodelling, and transcriptionfactor pathway redistribution. Its conformational flexibility enables highaffinity docking to catalytic residues, regulatory allosteric sites, transmembrane helices, scaffolding complexes, and cytoskeletal polymers. This results in crosssystem modulation spanning metabolic, structural, genomic and stressadaptive biological layers.
Mechanistically, the compound can perturb phosphorylation landscapes, alter propagation velocity across MAPK, JNK, ERK, p38 and PI3KAKT pathways, shift Gprotein signalling bias, redistribute intracellular Ca²⁺ waveforms, modulate cAMPPKA activity, and influence mitochondrial ROS leakage thresholds. Secondary messenger amplification, membranepotential polarity adjustments and ATP/ADP cycle reshaping are frequently observed across experimental substrates.
Advanced
QUINAPRIL HCL is applied in highprecision laboratory environments for:
- Deep kinomemapping and crosscascade interference modelling
- Receptorligand structural docking with metastability prediction
- Organellestress analysis including UPR, ER stress, mitochondrial oxidative load and mitophagy balance
- Multiomics transcriptome reconstruction with clustering of regulatory subnetworks
- Highresolution cytoskeletal dynamics mapping (actin tension, tubulin flux, scaffold integrity)
- Cellfate modelling across apoptosis, necroptosis, ferroptosis and autophagic flux states
- AIdriven SAR/QSAR modelling for compound performance optimisation
Toxicodynamics & Hazard Spectrum
At elevated or prolonged exposure, expected risks include:
- Acute ROS escalation with collapse of antioxidant buffering systems
- Mitochondrial fragmentation or electrontransport chain impairment
- Severe Ca²⁺/Na⁺/K⁺ ionchannel dysregulation
- Cytoskeletal depolymerisation causing mechanical instability
- Membrane rupture or lipidbilayer thinning
- Hyperactivation of inflammatory signalling (NF-κB, STAT families, IRF genes)
- Activation of programmed-cell-death pathways on multiple axes
- Epigenetic perturbation including methylation drift and histonemark imbalance
For expert not for any form of biological exposure.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H28N2O5·HCl |
|---|---|
| Molecular Weight | 475.0 g/mol |
| CAS Number | 82586-55-8 |
| Storage Condition | Storage: Store at controlled room temp 15-30 °C (59-86 °F). Protect from light. |
| Solubility | >71.2 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | QUINAPRIL HYDROCHLORIDE; 82586-55-8; QUINAPRIL HCL; Accuprin; Quinazil |
| IUPAC/Chemical Name | (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride |
| InChl Key | IBBLRJGOOANPTQ-JKVLGAQCSA-N |
| InChl Code | InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1 |
| References |
3D Conformer.
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