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Product Description
Mechanism of Action
PROPANOLOL HCL (ID 27268) demonstrates a high‑complexity biochemical interaction profile characterised by multilayer signalling integration, modular enzymatic pathway penetration, mitochondrial network modulation, ion‑flux recalibration, redox‑state equilibrium restructuring and transcription‑factor axis reprogramming. Its molecular geometry enables conformational docking to catalytic pockets, allosteric domains, transmembrane receptor helices and cytoskeletal scaffolds, creating broad regulatory influence across metabolic, structural and genomic systems.
At the signalling level, PROPANOLOL HCL may modulate phosphorylation gradients, kinome cascade propagation (including MAPK, JNK, ERK, PI3K–AKT, and AMPK axes), G‑protein subunit turnover, calcium wave propagation, secondary messenger amplification and stress‑adaptation thresholds. Mitochondrially, the compound can alter electron‑transport‑chain efficiency, ATP–ADP cycling, mitochondrial ROS leakage, membrane potential polarity and respiratory‑complex activation ratios.
Advanced Research Value
PROPANOLOL HCL is particularly suited for:
- Cross‑pathway interference mapping and kinome interaction grids
- Ultra‑high resolution receptor–ligand docking and conformational prediction
- Organelle‑stress modelling (ER stress, mitochondrial folding stress, autophagic flux modulation)
- Network‑level transcriptome rewiring using multi‑omics clustering
- Precision cytoskeletal‑mechanics analysis including actin polymerisation and tubulin turnover
- Apoptotic vs. survival‑pathway bias quantification
- Advanced SAR, QSAR and machine‑learning molecular‑performance modelling
Risks, Toxicodynamics & Cellular Hazard Spectrum
At elevated exposure levels, PROPANOLOL HCL may induce:
- ROS surge and oxidative collapse
- Mitochondrial hyperfragmentation or respiratory‑complex shutdown
- Severe ion‑channel destabilisation
- Cytoskeletal disassembly and membrane‑integrity breach
- Aberrant transcription‑factor activation, inflammatory bursts (NF‑κB, STAT, IRF pathways)
- High‑grade apoptosis, necroptosis or ferroptosis initiation
- Epigenetic instability affecting methylation/acetylation balance
Datasheet
| Molecular Formula | C16H21NO3·HCl |
|---|---|
| Molecular Weight | 295.8 g/mol |
| CAS Number | 318-98-9 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | propranolol; 525-66-6; Propanolol; beta-Propranolol; Betalong |
| IUPAC/Chemical Name | (2RS)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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