PROMIDIONE
Promidione is a fungicide that inhibits fungal growth by disrupting metabolic pathways. Although not used therapeutically in humans, exposure may cause skin or eye irritation, nausea, headache, and respiratory discomfort. Handling requires protective measures. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
PROMIDIONE demonstrates a highcomplexity biochemical interaction profile characterised by multilayer signalling integration, modular enzymatic pathway penetration, mitochondrial network modulation, ionflux recalibration, redoxstate equilibrium restructuring and transcriptionfactor axis reprogramming. Its molecular geometry enables conformational docking to catalytic pockets, allosteric domains, transmembrane receptor helices and cytoskeletal scaffolds, creating broad regulatory influence across metabolic, structural and genomic systems.
At the signalling level, PROMIDIONE may modulate phosphorylation gradients, kinome cascade propagation (including MAPK, JNK, ERK, PI3KAKT, and AMPK axes), Gprotein subunit turnover, calcium wave propagation, secondary messenger amplification and stressadaptation thresholds. Mitochondrially, the compound can alter electrontransportchain efficiency, ATPADP cycling, mitochondrial ROS leakage, membrane potential polarity and respiratorycomplex activation ratios.
Advanced Research Value
PROMIDIONE is particularly suited for:
- Crosspathway interference mapping and kinome interaction grids
- Ultrahigh resolution receptorligand docking and conformational prediction
- Organellestress modelling (ER stress, mitochondrial folding stress, autophagic flux modulation)
- Networklevel transcriptome rewiring using multiomics clustering
- Precision cytoskeletalmechanics analysis including actin polymerisation and tubulin turnover
- Apoptotic vs. survivalpathway bias quantification
- Advanced SAR, QSAR and machinelearning molecularperformance modelling
Risks, Toxicodynamics & Cellular Hazard Spectrum
At elevated exposure levels, PROMIDIONE may induce:
- ROS surge and oxidative collapse
- Mitochondrial hyperfragmentation or respiratorycomplex shutdown
- Severe ionchannel destabilisation
- Cytoskeletal disassembly and membrane-integrity breach
- Aberrant transcriptionfactor activation, inflammatory bursts (NF-κB, STAT, IRF pathways)
- Highgrade apoptosis, necroptosis or ferroptosis initiation
- Epigenetic instability affecting methylation/acetylation balance
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C13H13Cl2N3O3 |
|---|---|
| Molecular Weight | 330.16 g/mol |
| CAS Number | 36734-19-7 |
| Storage Condition | Do not contaminate water, food, or feed by storage … of this chemical. |
| Solubility | Solubility at 20 °C (g/l): ethanol 25; methanol 25; acetone 300; dichloromethane 500; dimethylformamide 500 |
| Purity | Purity information is available upon request (COA). |
| Synonym | IPRODIONE; 36734-19-7; Rovral; Glycophene; Promidione |
| IUPAC/Chemical Name | 3-(3,5-dichlorophenyl)-2,4-dioxo-N-propan-2-ylimidazolidine-1-carboxamide |
| InChl Key | ONUFESLQCSAYKA-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H13Cl2N3O3/c1-7(2)16-12(20)17-6-11(19)18(13(17)21)10-4-8(14)3-9(15)5-10/h3-5,7H,6H2,1-2H3,(H,16,20) |
| References |
3D Conformer.
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