PROMETHAZINE HCL
Promethazine HCl is a phenothiazine antihistamine that blocks H1 receptors and has strong sedative and antiemetic properties. It is used for allergy symptoms, motion sickness, nausea, and preoperative sedation. Side effects include drowsiness, dry mouth, blurred vision, constipation, hypotension, and rare neuroleptic reactions or respiratory depression, especially in children.
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Product Description
Mechanism of Action
PROMETHAZINE HCL (ID 27261) demonstrates a high‑complexity biochemical interaction profile characterised by multilayer signalling integration, modular enzymatic pathway penetration, mitochondrial network modulation, ion‑flux recalibration, redox‑state equilibrium restructuring and transcription‑factor axis reprogramming. Its molecular geometry enables conformational docking to catalytic pockets, allosteric domains, transmembrane receptor helices and cytoskeletal scaffolds, creating broad regulatory influence across metabolic, structural and genomic systems.
At the signalling level, PROMETHAZINE HCL may modulate phosphorylation gradients, kinome cascade propagation (including MAPK, JNK, ERK, PI3K–AKT, and AMPK axes), G‑protein subunit turnover, calcium wave propagation, secondary messenger amplification and stress‑adaptation thresholds. Mitochondrially, the compound can alter electron‑transport‑chain efficiency, ATP–ADP cycling, mitochondrial ROS leakage, membrane potential polarity and respiratory‑complex activation ratios.
Advanced Research Value
PROMETHAZINE HCL is particularly suited for:
- Cross‑pathway interference mapping and kinome interaction grids
- Ultra‑high resolution receptor–ligand docking and conformational prediction
- Organelle‑stress modelling (ER stress, mitochondrial folding stress, autophagic flux modulation)
- Network‑level transcriptome rewiring using multi‑omics clustering
- Precision cytoskeletal‑mechanics analysis including actin polymerisation and tubulin turnover
- Apoptotic vs. survival‑pathway bias quantification
- Advanced SAR, QSAR and machine‑learning molecular‑performance modelling
Risks, Toxicodynamics & Cellular Hazard Spectrum
At elevated exposure levels, PROMETHAZINE HCL may induce:
- ROS surge and oxidative collapse
- Mitochondrial hyperfragmentation or respiratory‑complex shutdown
- Severe ion‑channel destabilisation
- Cytoskeletal disassembly and membrane‑integrity breach
- Aberrant transcription‑factor activation, inflammatory bursts (NF‑κB, STAT, IRF pathways)
- High‑grade apoptosis, necroptosis or ferroptosis initiation
- Epigenetic instability affecting methylation/acetylation balance
Datasheet
| Molecular Formula | C17H21N2S·HCl |
|---|---|
| Molecular Weight | 320.9 g/mol |
| CAS Number | 58-33-3 |
| Storage Condition | Promethazine hydrochloride preparations should be protected from light. Promethazine hydrochloride oral solution and tablets should be stored in tight, light-resistant containers at 15-30 and 20-25 °C, respectively, while the rectal suppositories should be stored in well-closed containers at 2-8 °C. Freezing of the oral solution should be avoided. Following the date of manufacture, commercially available promethazine preparations have expiration dates of 2-5 years depending on the dosage form and manufacturer. |
| Solubility | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | PROMETHAZINE HYDROCHLORIDE; 58-33-3; Promethazine Hcl; Remsed; Promethacon |
| IUPAC/Chemical Name | N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine;hydrochloride |
| InChl Key | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H |
| References |
3D Conformer.
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