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Product Description
Mechanism of Action
PROCHLORPERAZINE MESYLATE (ID 27247) demonstrates a high‑complexity biochemical interaction profile characterised by multilayer signalling integration, modular enzymatic pathway penetration, mitochondrial network modulation, ion‑flux recalibration, redox‑state equilibrium restructuring and transcription‑factor axis reprogramming. Its molecular geometry enables conformational docking to catalytic pockets, allosteric domains, transmembrane receptor helices and cytoskeletal scaffolds, creating broad regulatory influence across metabolic, structural and genomic systems.
At the signalling level, PROCHLORPERAZINE MESYLATE may modulate phosphorylation gradients, kinome cascade propagation (including MAPK, JNK, ERK, PI3K–AKT, and AMPK axes), G‑protein subunit turnover, calcium wave propagation, secondary messenger amplification and stress‑adaptation thresholds. Mitochondrially, the compound can alter electron‑transport‑chain efficiency, ATP–ADP cycling, mitochondrial ROS leakage, membrane potential polarity and respiratory‑complex activation ratios.
Advanced Research Value
PROCHLORPERAZINE MESYLATE is particularly suited for:
- Cross‑pathway interference mapping and kinome interaction grids
- Ultra‑high resolution receptor–ligand docking and conformational prediction
- Organelle‑stress modelling (ER stress, mitochondrial folding stress, autophagic flux modulation)
- Network‑level transcriptome rewiring using multi‑omics clustering
- Precision cytoskeletal‑mechanics analysis including actin polymerisation and tubulin turnover
- Apoptotic vs. survival‑pathway bias quantification
- Advanced SAR, QSAR and machine‑learning molecular‑performance modelling
Risks, Toxicodynamics & Cellular Hazard Spectrum
At elevated exposure levels, PROCHLORPERAZINE MESYLATE may induce:
- ROS surge and oxidative collapse
- Mitochondrial hyperfragmentation or respiratory‑complex shutdown
- Severe ion‑channel destabilisation
- Cytoskeletal disassembly and membrane‑integrity breach
- Aberrant transcription‑factor activation, inflammatory bursts (NF‑κB, STAT, IRF pathways)
- High‑grade apoptosis, necroptosis or ferroptosis initiation
- Epigenetic instability affecting methylation/acetylation balance
Datasheet
| Molecular Formula | C22H32ClN3O6S3 |
|---|---|
| Molecular Weight | 566.2 g/mol |
| CAS Number | 51888-09-6 |
| Storage Condition | Commercially available preparations of prochlorperazine should be stored in tight, light-resistant containers. Prochlorperazine edisylate oral solutions and injection, and prochlorperazine maleate tablets and extended-release capsules should be stored at a temperature less than 40 °C, preferably between 15 -30 °C; freezing of the oral solutions and injection should be avoided. Prochlorperazine suppositories should be stored at a temperature less than 37 °C. Prochlorperazine edisylate injection should be protected from light, which can cause discoloration; if discoloration occurs, the injection should be discarded. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Prochlorperazine mesilate; 51888-09-6; Prochlorperazine Dimesylate; Prochlorperazine dimethanesulfonate; Prochlorperazine methanesulfonate |
| IUPAC/Chemical Name | 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine;methanesulfonic acid |
| InChl Key | BTOOUKJFDLARFG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H24ClN3S.2CH4O3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24;2*1-5(2,3)4/h2-3,5-8,15H,4,9-14H2,1H3;2*1H3,(H,2,3,4) |
| References |
3D Conformer.
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