PODOPHYLLOTOXIN
Podophyllin resin is a plantderived cytotoxic preparation that arrests mitosis and is used topically for wart treatment. Side effects include burning, ulceration, local necrosis, and systemic toxicity if applied excessively. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Scientific Overview
PODOPHYLLOTOXIN is a researchgrade biochemical compound used for advanced analytical, mechanistic and structural studies. It is often applied in laboratory environments requiring precise molecular behaviour, controlled pathway modulation and highfidelity reproducibility. The compound interacts with multiple biochemical systems depending on formulation, cell type and experimental conditions.
Mechanism of Action
Although the exact mechanism may vary by experimental model, PODOPHYLLOTOXIN typically exhibits activity involving:
- Enzymatic pathway modulation through reversible or irreversible interaction with catalytic sites
- Potential receptorlevel signaling effects influencing intracellular second messengers
- Alterations in redox balance and oxidativestress handling systems
- Mitochondrial functional modulation, including effects on ATP turnover and respiratorychain efficiency
- Influence on transcriptional behaviour, geneexpression clusters and regulatory protein networks
- Possible interaction with cytoskeletal structures affecting cellular stability and mechanical signaling
These combined effects make the compound suitable for multiaxis biochemical research.
Benefits and Applications
PODOPHYLLOTOXIN is commonly used for:
- Pathway validation and mechanistic investigation
- Bindingaffinity studies and structural modelling
- Metabolicflux analysis and mitochondrialfunction profiling
- Redox and oxidativestress research environments
- Cytoskeletal and membranedynamic studies
- Signaltransduction mapping across diverse biological systems
Risks and Safety Considerations
Potential risks associated with laboratory exposure include:
- Oxidative imbalance or ROS accumulation
- Mitochondrial stress or functional suppression at high concentrations
- Unintended receptor or enzyme crossinteraction
- Cytoskeletal destabilization or membrane disturbance
- Dosedependent cytotoxicity under prolonged exposure
Handle only with appropriate laboratory biosafety protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C22H22O8 |
|---|---|
| Molecular Weight | 414.4 g/mol |
| CAS Number | 518-28-5 |
| Storage Condition | Podofilox topical gel and topical solution should be stored at 15-30 °C. These preparations should not be exposed to excessive heat; freezing should be avoided. … |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | podophyllotoxin; Podofilox; 518-28-5; Condylox; (-)-Podophyllotoxin |
| IUPAC/Chemical Name | (5R,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one |
| InChl Key | YJGVMLPVUAXIQN-XVVDYKMHSA-N |
| InChl Code | InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1 |
| References |
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