PENCICLOVIR
Penciclovir is a guanine nucleoside analogue that is phosphorylated in virus‑infected cells and inhibits viral DNA polymerase, halting DNA synthesis. It is used topically for herpes labialis. Benefits include shortened lesion duration and symptom relief. Side effects are usually mild and include local burning, numbness, erythema, and rare allergic skin reactions.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
PENCICLOVIR (ID 27043) demonstrates a multidimensional biochemical activity pattern, affecting enzyme‑regulated catalytic networks, receptor‑mediated intracellular signalling, mitochondrial respiratory pathways, oxidative‑stress regulation, ion‑channel behaviour, cytoskeletal mechanics and transcription‑factor network modulation. Structural evidence suggests potential interactions with catalytic residues, allosteric domains, transmembrane protein complexes, regulatory scaffolds and intracellular signalling intermediates. These interactions allow PENCICLOVIR to influence phosphorylation kinetics, second‑messenger signalling (Ca²⁺, cAMP, IP₃, DAG), redox‑buffering systems, ATP turnover rates and mitochondrial membrane‑potential stability.
Depending on experimental conditions, PENCICLOVIR may alter metabolic flux distribution, cytoskeletal tension, vesicular transport efficiency, chromatin‑accessibility patterns and gene‑expression networks related to stress responses, inflammation, apoptosis, autophagy and metabolic adaptation.
Benefits and Advantages
This compound is widely used across high‑resolution biochemical and pharmacological research areas, including:
- Receptor–ligand interaction analysis and affinity‑mapping
- Detailed enzyme‑kinetics profiling and catalytic‑pathway evaluation
- Mitochondrial‑dynamics studies, ATP‑flux modelling and oxidative‑stress research
- Integrated multi‑omics applications (transcriptomics, metabolomics, proteomics, phosphoproteomics)
- Cytoskeletal and membrane‑mechanics modelling
- Apoptosis, necroptosis, ferroptosis and autophagy signalling pathway studies
- SAR (structure–activity relationship) and molecular‑optimisation pipelines
- Mechanistic pharmacodynamic modelling and threshold‑activation experiments
Side Effects and Risks
Laboratory‑observed risks include:
- Oxidative‑stress imbalance and ROS overproduction
- Mitochondrial overload or suppression of respiratory‑chain complexes
- Dysregulation of Na⁺/K⁺/Ca²⁺ transport and ion‑channel behaviour
- Unintended receptor cross‑talk or inhibitory interference
- Cytoskeletal destabilisation and membrane‑integrity compromise
- Dose‑dependent cytotoxicity leading to apoptosis or autophagy
- Transcriptional instability or inflammatory signalling activation (NF‑κB, JNK, MAPK)
Use exclusively under controlled laboratory conditions with strict biosafety procedures.
Datasheet
| Molecular Formula | C10H15N5O3 |
|---|---|
| Molecular Weight | 253.26 g/mol |
| CAS Number | 39809-25-1 |
| Storage Condition | Store at controlled room temperature, 20-25 °C (68 -77 °F). |
| Solubility | 1.7mg/ml |
| Purity | Purity information is available upon request (COA). |
| Synonym | penciclovir; 39809-25-1; Denavir; BRL-39123; Penciclovirum |
| IUPAC/Chemical Name | 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-1H-purin-6-one |
| InChl Key | JNTOCHDNEULJHD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
