About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
MESALAZINE (ID 26658) displays a broad and multi‑axis biochemical interaction profile characterised by modulation of enzymatic networks, receptor‑mediated signalling, intracellular ion regulation, mitochondrial bioenergetics and transcriptional pathway governance. Its structural features suggest interactions with catalytic and regulatory proteins, leading to changes in phosphorylation cycles, metabolic flux, mitochondrial redox balance, calcium‑signalling behaviour and stress‑response activation. Depending on cellular environment and concentration, the compound may act as an activator, inhibitor or regulatory modulator.
Benefits and Advantages
This compound supports a wide range of research applications, including:
- Receptor–ligand affinity profiling and binding‑site mapping
- Enzyme‑cascade modelling and catalytic‑domain interaction studies
- Mitochondrial‑function assays, oxidative‑stress evaluation and metabolic‑flux tracking
- Transcriptomic, proteomic and metabolomic investigation for pathway mapping
- Apoptosis / autophagy pathway research and cellular‑stress modelling
- High‑resolution mechanism‑of‑action studies and SAR exploration
Side Effects and Risks
Potential risks include oxidative imbalance, mitochondrial overload, ion‑channel dysregulation, receptor cross‑talk, cytoskeletal disruption and dose‑dependent cytotoxicity. At elevated exposure levels, the compound may induce apoptosis, autophagy, inflammatory signalling, metabolic reprogramming or transcriptional instability. Proper laboratory controls and strict biosafety procedures are required for handling.
Datasheet
| Molecular Formula | C7H7NO3 |
|---|---|
| Molecular Weight | 153.14 g/mol |
| CAS Number | 89-57-6 |
| Storage Condition | Commercially available oral mesalamine delayed-release tablets should be stored at a controlled room temperature of 20-25 °C, while the commercially available oral extended-release capsules should be stored at 25 °C but may be exposed to temperatures ranging from 15-30 °C. |
| Solubility | less than 1 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | 5-Aminosalicylic acid; mesalamine; Mesalazine; 89-57-6; 5-Amino-2-hydroxybenzoic acid |
| IUPAC/Chemical Name | 5-amino-2-hydroxybenzoic acid |
| InChl Key | KBOPZPXVLCULAV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,10,11) |
| References |
3D Conformer.
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