LIOTHYRONINE SODIUM
Liothyronine sodium is a synthetic form of triiodothyronine (T3) that increases metabolic rate, oxygen consumption, and protein synthesis. It is used for hypothyroidism and certain thyroid function tests. Side effects include palpitations, weight loss, anxiety, insomnia, and potential arrhythmias if overdosed.
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Product Description
Mechanism of Action
LIOTHYRONINE SODIUM (ID 26565) demonstrates a high‑complexity biochemical profile involving modulation of receptor systems, enzyme‑regulated metabolic pathways, mitochondrial performance, intracellular ion dynamics and transcription‑level regulation. Its structural properties support binding to catalytic and regulatory protein domains, altering phosphorylation cascades, redox‑state equilibrium, cellular stress‑response thresholds and mitochondrial signalling output.
The molecule may influence calcium flux, ATP turnover, ROS–antioxidant balance, cytoskeletal organisation and membrane‑potential stability depending on the biological system and concentration applied.
Benefits and Advantages
Widely applied in mechanistic and pharmacodynamic research, including:
- Receptor‑ligand interaction analysis and affinity profiling
- Enzyme‑kinetic and catalytic‑pathway investigations
- Mitochondrial‑function, metabolic‑flux and oxidative‑stress studies
- Multi‑omics research: transcriptomics, proteomics and metabolomics
- Cell‑stress signalling, apoptosis/autophagy modelling and cytoskeletal‑dynamics mapping
- Preclinical screening, SAR modelling and comparative mechanistic benchmarking
Side Effects and Risks
Potential risks include oxidative imbalance, mitochondrial strain, unintended receptor cross‑activation, ion‑channel perturbation, metabolic rewiring, and dose‑dependent cytotoxicity. High exposure may induce apoptosis, autophagy, inflammatory signalling or transcriptional destabilisation. Strict laboratory safety protocols and controlled handling conditions are required.
Datasheet
| Molecular Formula | C15H11I3NNaO4 |
|---|---|
| Molecular Weight | 672.95 g/mol |
| CAS Number | 55-06-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | LIOTHYRONINE SODIUM; 55-06-1; 3,3',5-Triiodo-L-thyronine sodium salt; Triostat; Basoprocin |
| IUPAC/Chemical Name | sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate |
| InChl Key | SBXXSUDPJJJJLC-YDALLXLXSA-M |
| InChl Code | InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1 |
| References |
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