KETOLITHOCHOLIC ACID
Ketolithocholic acid is a bile acid derivative involved in bile flow and lipid digestion, and is used mainly in biochemical and metabolic research. Benefits include utility as a tool compound for studying bile acid pathways. Side effects are not clinically defined but exposure may cause irritation or GI upset. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
KETOLITHOCHOLIC ACID exhibits a structured and multilayered biochemical activity profile involving modulation of enzymatic cascades, receptorbinding dynamics, intracellular signalling architecture, and metabolicflux regulation. Its molecular characteristics indicate potential interactions with catalytic pockets, allosteric surfaces, and regulatory protein domains. Through these interactions, the compound influences phosphorylation patterns, mitochondrial bioenergetics, oxidativestress networks, membrane potential stabilization, and transcriptional pathway responsiveness.
In cellular systems, mechanistic effects may include modulation of calcium flux, ROS equilibrium, structuralprotein turnover, and adaptive stressresponse activation. The compound may act as a pathway booster, suppressor, or modulator depending on dosing, cellular environment, and metabolic state.
Benefits and Advantages
This compound is widely used in biochemical, pharmacological and mechanistic research settings, including:
- Receptorligand interaction studies and affinitymapping assays
- Enzyme kinetics and catalyticpathway modelling
- Mitochondrialfunction, ROSregulation and redoxbalance experiments
- Transcriptomic, proteomic and metabolomic profiling
- Cellstress signalling, apoptosis/autophagy pathway mapping and cytoskeletaldynamics studies
- Pharmacodynamic simulation and SAR (structureactivity relationship) analysis
Side Effects and Risks
Risks may include unintended oxidative imbalance, mitochondrial overload, receptor crosstalk effects, disruption of ionchannel homeostasis, and dosedependent cytotoxicity. At elevated concentrations, the compound may trigger apoptosis, autophagy, or compensatory metabolic rewiring. Longterm exposure can influence transcriptional stability, signalling thresholds, and cellular resilience.
Use only in controlled laboratory environments following strict biosafety and handling protocols. Not intended for human or veterinary use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C24H38O3 |
|---|---|
| Molecular Weight | 374.55 g/mol |
| CAS Number | 475-31-0 |
| Storage Condition | Store at 2-8°C |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Urosodeoxycholic Acid Impurity 11; 3beta-GlycocholicAcid; N-CHOLYLGLYCINE; Glycine, N-[(3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-trihydroxy-24-oxocholan-24-yl]-; SCHEMBL15195576 |
| IUPAC/Chemical Name | 3α-hydroxy-5β-cholan-24-oic acid |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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