ITRACONAZOLE
Itraconazole is a triazole antifungal that inhibits fungal cytochrome P450dependent synthesis of ergosterol, disrupting cell membrane integrity. It is used to treat systemic and superficial mycoses. Benefits include broadspectrum activity and oral dosing options. Side effects may include liver enzyme elevation, GI upset, edema, drug interactions, and rarely heart failure in predisposed patients. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
ITRACONAZOLE exhibits a structured and multilayered biochemical activity profile involving modulation of enzymatic cascades, receptorbinding dynamics, intracellular signalling architecture, and metabolicflux regulation. Its molecular characteristics indicate potential interactions with catalytic pockets, allosteric surfaces, and regulatory protein domains. Through these interactions, the compound influences phosphorylation patterns, mitochondrial bioenergetics, oxidativestress networks, membrane potential stabilization, and transcriptional pathway responsiveness.
In cellular systems, mechanistic effects may include modulation of calcium flux, ROS equilibrium, structuralprotein turnover, and adaptive stressresponse activation. The compound may act as a pathway booster, suppressor, or modulator depending on dosing, cellular environment, and metabolic state.
Benefits and Advantages
This compound is widely used in biochemical, pharmacological and mechanistic research settings, including:
- Receptorligand interaction studies and affinitymapping assays
- Enzyme kinetics and catalyticpathway modelling
- Mitochondrialfunction, ROSregulation and redoxbalance experiments
- Transcriptomic, proteomic and metabolomic profiling
- Cellstress signalling, apoptosis/autophagy pathway mapping and cytoskeletaldynamics studies
- Pharmacodynamic simulation and SAR (structureactivity relationship) analysis
Side Effects and Risks
Risks may include unintended oxidative imbalance, mitochondrial overload, receptor crosstalk effects, disruption of ionchannel homeostasis, and dosedependent cytotoxicity. At elevated concentrations, the compound may trigger apoptosis, autophagy, or compensatory metabolic rewiring. Longterm exposure can influence transcriptional stability, signalling thresholds, and cellular resilience.
Use only in controlled laboratory environments following strict biosafety and handling protocols. Not intended for human or veterinary use.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C35H38Cl2N8O4 |
|---|---|
| Molecular Weight | 705.6 g/mol |
| CAS Number | 84625-61-6 |
| Storage Condition | Itraconazole capsules should be stored at a controlled room temperature of 15-25 °C and protected from light and moisture. Itraconazole oral solution should be stored at 25 °C or lower and should not be frozen. |
| Solubility | Practically insoluble in water and dilute acidic solutions |
| Purity | Purity information is available upon request (COA). |
| Synonym | itraconazole; 84625-61-6; Oriconazole; Sporanox; Itraconazol |
| IUPAC/Chemical Name | 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one |
| InChl Key | VHVPQPYKVGDNFY-ZPGVKDDISA-N |
| InChl Code | InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1 |
| References |
3D Conformer.
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