HYDROXYZINE HCL
Hydroxyzine HCl is an antihistamine with anxiolytic and sedative effects by blocking H1 receptors. Side effects include drowsiness, dry mouth, and impaired coordination.
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Product Description
Mechanism of Action
HYDROXYZINE HCL (ID 26385) exhibits a multi-dimensional biochemical activity profile that affects cellular regulation at enzyme, receptor, and transcriptional levels. Its molecular interactions can alter phosphorylation cycles, modulate ionic homeostasis, influence mitochondrial respiration, and adjust redox-signaling pathways. Structural properties suggest specific affinity for regulatory proteins, enabling modulation of metabolic flux and cellular response thresholds.
Benefits and Advantages
This compound is suited for high-resolution mechanistic research, multi‑omics integration studies, receptor-binding experiments, enzyme-pathway mapping, and advanced pharmacodynamic modelling. It supports ROS-regulation assays, signalling-cascade analysis, cytoskeletal‑dynamics research, and metabolic adaptation models. Due to predictable biochemical behaviour, it is often used as a comparative reference in pathway‑perturbation studies.
- Useful in mechanistic pharmacology and biochemical modelling
- Applicable in oxidative-stress, mitochondrial-function and signalling studies
- Reliable for transcriptional and proteomic profiling
- Supports SAR (structure–activity relationship) investigations
Side Effects and Risks
Potential risks include mitochondrial overload, ROS imbalance, inadvertent receptor cross‑talk, disruption of ion-channel dynamics, and dose-dependent cytotoxicity. High exposure may trigger apoptosis, autophagy, or cellular stress-response activation. Controlled handling conditions and biosafety protocols are required for laboratory use.
Datasheet
| Molecular Formula | C21H27ClN2O2·HCl |
|---|---|
| Molecular Weight | 447.8 g/mol |
| CAS Number | 2192-20-3 |
| Storage Condition | Commercially available preparations of hydroxyzine should be stored in tight, light-resistant containers at a temperature less than 40 °C, preferably at 15 – 30 °C; freezing of the oral solution, oral suspension, or injection should be avoided. |
| Solubility | Crystals; MP 193 °C; Bitter taste. Solubility in mg/mL: water <700; chloroform 60; acetone 2; ether <0.1. Solutions are unstable to intense UV light. /Hydroxyzine dihydrochloride/ |
| Purity | Purity information is available upon request (COA). |
| Synonym | Hydroxyzine dihydrochloride; 2192-20-3; Hydroxyzine hydrochloride; Orgatrax; Hydroxyzine Hcl |
| IUPAC/Chemical Name | 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol;dihydrochloride |
| InChl Key | ANOMHKZSQFYSBR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H |
| References |
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