About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Gemcitabine is a difluorinated deoxycytidine analogue that incorporates into DNA, causing chain termination, and inhibits ribonucleotide reductase, reducing dNTP pools needed for replication.
Benefits and Advantages
Used in cytotoxicity assays, DNA-synthesis studies, replication-stress research and oncology drug screening.
Side Effects and Risks
Myelosuppression, hepatotoxicity, pulmonary toxicity and flu-like symptoms. Handle as a potent antimetabolite.
Datasheet
| Molecular Formula | C9H11F2N3O4 |
|---|---|
| Molecular Weight | 263.20 g/mol |
| CAS Number | 95058-81-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | gemcitabine; 95058-81-4; 2'-Deoxy-2',2'-difluorocytidine; 2',2'-Difluorodeoxycytidine; dFdC |
| IUPAC/Chemical Name | 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| InChl Key | SDUQYLNIPVEERB-QPPQHZFASA-N |
| InChl Code | InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1 |
| References |
3D Conformer.
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