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Product Description
Mechanism of Action
Gadodiamide is a nonionic, linear gadolinium‑based contrast agent (GBCA) in which Gd³⁺ is chelated by a diethylenetriaminepentaacetic acid‑bismethylamide ligand. It shortens T1 and T2 relaxation times of nearby water protons, enhancing MRI signal intensity in perfused tissues.
Benefits and Advantages
Used in MR angiography, perfusion imaging, blood–brain barrier integrity studies and contrast‑agent pharmacokinetic research.
Side Effects and Risks
Risks include nephrogenic systemic fibrosis (in severe renal impairment), gadolinium retention, hypersensitivity reactions and mild nausea. Handle with GBCA‑class precautions and renal‑function assessment.
Datasheet
| Molecular Formula | C16H26GdN5O8 |
|---|---|
| Molecular Weight | 573.66 g/mol |
| CAS Number | 131410-48-5 |
| Storage Condition | Protect Omniscan from strong daylight and direct exposure to sunlight. Do not freeze. Freezing can cause small cracks in the vials, which would compromise the sterility of the product. Do not use if the product is inadvertently frozen. Store Omniscan at controlled room temperature 20 deg -25 °C (68 deg -77 °F); excursions permitted to 15 deg -30 °C (59 deg -86 °F). |
| Solubility | Freely soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | gadodiamide; 131410-48-5; GDDTPA-BMA; Gadodiamide anhydrous; Gadolinium-DTPA-BMA |
| IUPAC/Chemical Name | 2-[bis[2-[carboxylatomethyl-[2-(methylamino)-2-oxoethyl]amino]ethyl]amino]acetate;gadolinium(3+) |
| InChl Key | HZHFFEYYPYZMNU-UHFFFAOYSA-K |
| InChl Code | InChI=1S/C16H29N5O8.Gd/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3 |
| References |
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