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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Floxuridine (FUDR) is a fluorinated pyrimidine analogue that is converted intracellularly to FdUMP, inhibiting thymidylate synthase and impairing DNA synthesis, especially in rapidly dividing cells.
Benefits and Advantages
Used in DNA‑synthesis inhibition studies, thymidylate‑synthase research and oncologic cytotoxicity assays.
Side Effects and Risks
Myelosuppression, mucositis, hepatotoxicity and GI toxicity.
Datasheet
| Molecular Formula | C9H11FN2O5 |
|---|---|
| Molecular Weight | 246.19 g/mol |
| CAS Number | 50-91-9 |
| Storage Condition | Floxuridine sterile powder should be protected from light and stored at 15-30 °C. In the dry state, floxuridine has an expiration date of 3 years following the date of manufacture. Reconstituted floxuridine injection should be stored at 2-8 °C and used within 2 weeks. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | floxuridine; 50-91-9; 5-Fluorodeoxyuridine; 2'-Deoxy-5-fluorouridine; Fluorodeoxyuridine |
| IUPAC/Chemical Name | 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| InChl Key | ODKNJVUHOIMIIZ-RRKCRQDMSA-N |
| InChl Code | InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| References |
3D Conformer.
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