ETHIONAMIDE

Ethionamide is a second-line antitubercular drug inhibiting mycolic acid synthesis in Mycobacterium tuberculosis. Side effects include hepatotoxicity, GI upset, and neurological symptoms such as peripheral neuropathy. Only GMP materials will be supplied, logistics all according to GDP.

SKU: cb3694b3f6cd Category: Tag:

Request a quote now

About MedicaPharma

MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.

Network of over +400 GMP API producers

Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.

Why Choose MedicaPharma

Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations

Product Description


Mechanism of Action

Ethionamide is a prodrug activated by mycobacterial monooxygenase (EtaA). The activated form inhibits InhA, an enoylACP reductase required for mycolicacid synthesis, thereby disrupting the integrity of the mycobacterial cell wall.

Benefits and Advantages

Used in TBpathway research, prodrugactivation assays, mycolicacid biosynthesis studies, and multidrugresistance modelling.

Side Effects and Risks

Risks include hepatotoxicity, GI intolerance, neurotoxicity and hypothyroidism. Handle with antimycobacterialthioamide precautions.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C8H10N2S

Molecular Weight

166.25 g/mol

CAS Number

536-33-4

Storage Condition

Ethionamide film-coated tablets should be stored in tight containers at 20-25 °C.

Solubility

less than 1 mg/mL at 70 °F (NTP, 1992)

Purity

Purity information is available upon request (COA).

Synonym

ethionamide; 536-33-4; 2-ethylpyridine-4-carbothioamide; Trecator; Ethioniamide

IUPAC/Chemical Name

2-ethylpyridine-4-carbothioamide

InChl Key

AEOCXXJPGCBFJA-UHFFFAOYSA-N

InChl Code

InChI=1S/C8H10N2S/c1-2-7-5-6(8(9)11)3-4-10-7/h3-5H,2H2,1H3,(H2,9,11)

References

https://pubchem.ncbi.nlm.nih.gov/compound/2761171;

Request a quote now

3D Conformer.

(Click, turn or enlarge)

Download our GMP API Product List.

MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.

Download