About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Erlotinib is a selective small‑molecule inhibitor of EGFR (ErbB1) tyrosine kinase. It binds the ATP‑binding site of EGFR, blocking autophosphorylation and downstream signalling across the RAS–RAF–MEK–ERK and PI3K–AKT pathways. It is particularly effective in EGFR‑activating mutation models.
Benefits and Advantages
Used in EGFR‑pathway research, kinase‑inhibition profiling, oncogene‑driven tumour modelling, and resistance‑mutation evolution assays.
Side Effects and Risks
Risks include rash, diarrhea, hepatotoxicity, interstitial lung disease (rare) and photosensitivity. Handle with EGFR‑inhibitor precautions.
Datasheet
| Molecular Formula | C22H23N3O4 |
|---|---|
| Molecular Weight | 393.4 g/mol |
| CAS Number | 183321-74-6 |
| Storage Condition | Store at 25 °C (77 °F); excursions permitted to 15 – 30 °C (59 – 86 °F). |
| Solubility | Very slightly soluble (hydrochloride salt – maximal solubility of approximately 0.4 mg/mL occurs at a pH of approximately 2) |
| Purity | Purity information is available upon request (COA). |
| Synonym | Erlotinib; 183321-74-6; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; 4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-; erlotinibum |
| IUPAC/Chemical Name | N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine |
| InChl Key | AAKJLRGGTJKAMG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) |
| References |
3D Conformer.
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