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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Duloxetine is a serotoninnorepinephrine reuptake inhibitor (SNRI) that increases synaptic concentrations of 5HT and NE. It enhances descending inhibitory pain pathways and modulates moodrelated neural circuits. It also influences central nociceptive processing, making it effective in neuropathicpain models.
Benefits and Advantages
Used in monoaminetransporter research, chronicpain signalling studies, SNRImechanism modelling, and neuropsychiatric pharmacodynamics.
Side Effects and Risks
Risks include hypertension, nausea, insomnia, serotonin syndrome (with combinations), hepatotoxicity and withdrawal symptoms. Handle with SNRIclass precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H19NOS |
|---|---|
| Molecular Weight | 297.4 g/mol |
| CAS Number | 116539-59-4 |
| Storage Condition | Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature -20 °C |
| Solubility | 2.96e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | duloxetine; 116539-59-4; (S)-Duloxetine; Yentreve; 2-Thiophenepropanamine, N-methyl-gamma-(1-naphthalenyloxy)-, (gammaS)- |
| IUPAC/Chemical Name | (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine |
| InChl Key | ZEUITGRIYCTCEM-KRWDZBQOSA-N |
| InChl Code | InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 |
| References |
3D Conformer.
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