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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Doxepin hydrochloride is a tricyclic antidepressant with strong antagonism of H₁‑histamine receptors and moderate inhibition of norepinephrine and serotonin reuptake transporters. It stabilizes mood through monoamine elevation and produces profound antihistaminic sedation due to its very high H₁ affinity.
Benefits and Advantages
Used in depression‑modelling research, histamine‑receptor antagonism assays, sleep‑modulation studies, monoamine‑transporter SAR studies and chronic‑stress pathway modelling.
Side Effects and Risks
Risks include sedation, anticholinergic effects, weight gain, QT prolongation, arrhythmias and overdose toxicity. Handle with TCA‑class CNS‑active precautions.
Datasheet
| Molecular Formula | C19H21NO·HCl |
|---|---|
| Molecular Weight | 315.8 g/mol |
| CAS Number | 1229-29-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Doxepin Hydrochloride; 1229-29-4; Doxepin HCl; Adapin; Silenor |
| IUPAC/Chemical Name | (3E)-3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine;hydrochloride |
| InChl Key | MHNSPTUQQIYJOT-SJDTYFKWSA-N |
| InChl Code | InChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+; |
| References |
3D Conformer.
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