About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Disulfiram is an aldehyde dehydrogenase (ALDH) inhibitor that blocks the oxidation of acetaldehyde to acetic acid. In the presence of ethanol, acetaldehyde accumulates, producing flushing, tachycardia, nausea and hypotensionan aversive reaction that discourages alcohol consumption. It also inhibits dopamine hydroxylase and interacts with metaldependent enzymes.
Benefits and Advantages
Used in alcoholdeterrent mechanism studies, ALDHenzyme research, addictionpathway modelling, and metalchelation/thiuram disulfide interaction assays.
Side Effects and Risks
Risks include hepatotoxicity, neuropathy, psychosis, severe disulfiramethanol reaction, dermatologic reactions and drugdrug interactions. Handle with enzymeinhibitor and hepatotoxiccompound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C10H20N2S4 |
|---|---|
| Molecular Weight | 296.5 g/mol |
| CAS Number | 97-77-8 |
| Storage Condition | Commercially available disulfiram tablets should be protected from light and stored in tight, light-resistant containers at a temperature less than 40 °C preferably between 15-30 °C. Oral suspensions of disulfiram have been prepared extemporaneously from commercially available tablets of the drug. A suspension of 1% disulfiram, 1/4% methylcellulose, and 10% Tang /breakfast drink/ in distilled water has been reported to be stable for up to 6 months if refrigerated at 2-8 °C and protected from light. |
| Solubility | less than 0.1 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | disulfiram; Tetraethylthiuram disulfide; 97-77-8; Antabuse; Bis(diethylthiocarbamoyl) disulfide |
| IUPAC/Chemical Name | diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate |
| InChl Key | AUZONCFQVSMFAP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3 |
| References |
3D Conformer.
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