About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Diflunisal is a salicylic‑acid derivative NSAID that non‑competitively inhibits cyclooxygenase enzymes (COX‑1 and COX‑2). This decreases prostaglandin synthesis, reducing inflammation, pain and fever. Its difluorophenyl ring confers longer half‑life and reduced CNS penetration compared to aspirin.
Benefits and Advantages
Used in COX‑pathway modelling, analgesic SAR research, prostaglandin signalling analysis, and inflammatory‑cascade studies.
Side Effects and Risks
Risks include GI irritation, renal stress, bleeding tendency, hypersensitivity, hepatotoxicity and fluid retention. Handle with NSAID‑class safety procedures.
Datasheet
| Molecular Formula | C13H8F2O3 |
|---|---|
| Molecular Weight | 250.20 g/mol |
| CAS Number | 22494-42-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Practically insoluble (14.5 mg/L) at neutral or acidic pH. |
| Purity | Purity information is available upon request (COA). |
| Synonym | diflunisal; 22494-42-4; Dolobid; Dolobis; Flovacil |
| IUPAC/Chemical Name | 5-(2,4-difluorophenyl)-2-hydroxybenzoic acid |
| InChl Key | HUPFGZXOMWLGNK-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18) |
| References |
3D Conformer.
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