CISATRACURIUM BESYLATE
Cisatracurium besylate is a non‑depolarizing neuromuscular blocker that inhibits acetylcholine at the neuromuscular junction, producing controlled muscle relaxation during anesthesia. Benefits include predictable onset and organ‑independent Hofmann elimination. Side effects may include hypotension, flushing, and prolonged paralysis.
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Product Description
Mechanism of Action
Cisatracurium besylate is a non-depolarizing neuromuscular blocker that competitively antagonizes nicotinic acetylcholine receptors at the neuromuscular junction. This prevents depolarization and produces skeletal muscle relaxation. It undergoes Hofmann elimination, making clearance less dependent on renal or hepatic function.
Benefits and Advantages
Used in neuromuscular-junction research, receptor-occupancy studies, anaesthesia-modelling experiments, electrophysiology assays and chemical degradation-pathway studies (Hofmann elimination kinetics).
Side Effects and Risks
Risks include hypotension, bronchospasm, prolonged paralysis (rare), histamine release and respiratory depression. Handle with paralytic-agent precautions.
Datasheet
| Molecular Formula | C65H82N2O18S2 |
|---|---|
| Molecular Weight | 1243.5 g/mol |
| CAS Number | 96946-42-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Miscible |
| Purity | Purity information is available upon request (COA). |
| Synonym | Cisatracurium besylate; 96946-42-8; Nimbex; Cisatracurium besilate; NIMBEX PRESERVATIVE FREE |
| IUPAC/Chemical Name | benzenesulfonate;5-[3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoyloxy]pentyl 3-[(1R,2R)-1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoate |
| InChl Key | XXZSQOVSEBAPGS-DONVQRBFSA-L |
| InChl Code | InChI=1S/C53H72N2O12.2C6H6O3S/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6;2*7-10(8,9)6-4-2-1-3-5-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3;2*1-5H,(H,7,8,9)/q+2;;/p-2/t42-,43-,54-,55-;;/m1../s1 |
| References |
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