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Product Description
Mechanism of Action
Cinnarizine is a calcium‑channel blocker with antihistaminic (H₁) and anti‑vertigo properties. It inhibits L‑type calcium channels, reducing smooth‑muscle contractility, while its H₁‑antagonism suppresses vestibular nuclei excitability—useful in motion‑sickness research. It also improves microcirculation by reducing blood viscosity.
Benefits and Advantages
Used in vestibular‑function studies, motion‑sickness modelling, calcium‑channel pharmacology, cerebral‑perfusion research and combined antihistamine–vasodilator SAR investigations.
Side Effects and Risks
Risks include sedation, weight gain, extrapyramidal symptoms (rare), dry mouth and hypotension. Handle with CNS‑active calcium‑antagonist precautions.
Datasheet
| Molecular Formula | C26H28N2 |
|---|---|
| Molecular Weight | 368.5 g/mol |
| CAS Number | 298-57-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 1.72e-03 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | cinnarizine; 298-57-7; Stugeron; Dimitron; Folcodal |
| IUPAC/Chemical Name | 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine |
| InChl Key | DERZBLKQOCDDDZ-JLHYYAGUSA-N |
| InChl Code | InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+ |
| References |
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